Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 8/20 | 0.61 |
| ▸ | KLK1 | P06870 | 3/20 | 0.61 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.61 |
| ▸ | TMPRSS15 | P98073 | 6/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.46 |
| ▸ | F2 | P00734 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4752946 | 0.83 | PRSS1 (0.66) | PRSS1KLK1TMPRSS2TMPRSS15PRSS2 | |
| SCHEMBL15571972 | 0.80 | PRSS1 (0.70) | PRSS1KLK1TMPRSS2TMPRSS15PRSS2 | |
| SCHEMBL4752930 | 0.79 | PRSS1 (0.61) | PRSS1KLK1TMPRSS2TMPRSS15PRSS2 | |
| SCHEMBL11417275 | 0.77 | PRSS1 (0.67) | PRSS1KLK1TMPRSS2TMPRSS15PRSS2 | |
| SCHEMBL8660216 | 0.77 | PRSS1 (0.64) | PRSS1KLK1TMPRSS2TMPRSS15SRD5A2 | |
| SCHEMBL1649708 | 0.75 | PRSS1 (1.00) | PRSS1KLK1TMPRSS2TMPRSS15PRSS2 | |
| Hydrochloric Acid SCHEMBL7563142 | 0.72 | TP53 (0.44) | PRSS1PRSS2PRSS3F2KDM4E | |
| Hydrochloric Acid SCHEMBL7563152 | 0.72 | TP53 (0.44) | PRSS1PRSS2PRSS3F2KDM4E | |
| SCHEMBL23001575 | 0.72 | FTO (0.48) | PRSS1KLK1TMPRSS2TMPRSS15PRSS2 | |
| SCHEMBL11313907 | 0.69 | PRSS1 (0.49) | PRSS1KLK1TMPRSS2TMPRSS15PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008142397-A1 | SERINE PROTEASE INHIBITORS FOR USE IN THE TREATMENT OF BACTERIAL INFECTIONS | SERENTIS LIMITED (GB) | 2008-11-27 | — | — | WO | disclosed |