Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 5/20 | 0.66 |
| ▸ | KLK1 | P06870 | 4/20 | 0.66 |
| ▸ | F2 | P00734 | 2/20 | 0.66 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.66 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.66 |
| ▸ | HPN | P05981 | 1/20 | 0.66 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.66 |
| ▸ | CTSL | P07711 | 1/20 | 0.66 |
| ▸ | CNR1 | P21554 | 1/20 | 0.66 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.66 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.66 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.66 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.66 |
| ▸ | KLK7 | P49862 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15571972 | 0.97 | PRSS1 (0.70) | PRSS1KLK1F2TMPRSS2SLC22A2 | |
| SCHEMBL4752931 | 0.83 | PRSS1 (0.61) | PRSS1KLK1F2TMPRSS2PRSS2 | |
| Camostat SCHEMBL125269 | 0.82 | PRSS1 (0.68) | PRSS1KLK1F2TMPRSS2SLC22A2 | |
| SCHEMBL13283061 | 0.82 | PRSS1 (0.68) | PRSS1KLK1F2TMPRSS2SLC22A2 | |
| SCHEMBL20008640 | 0.82 | PRSS1 (0.68) | PRSS1KLK1F2TMPRSS2SLC22A2 | |
| Camostat SCHEMBL2782237 | 0.81 | PRSS1 (0.67) | PRSS1KLK1F2TMPRSS2SLC22A2 | |
| Camostat SCHEMBL871583 | 0.80 | PRSS1 (0.72) | PRSS1KLK1F2TMPRSS2SLC22A2 | |
| Camostat SCHEMBL8829828 | 0.80 | PRSS1 (0.66) | PRSS1KLK1F2TMPRSS2SLC22A2 | |
| SCHEMBL21920058 | 0.80 | PRSS1 (0.74) | PRSS1KLK1F2TMPRSS2SLC22A2 | |
| Camostat SCHEMBL1646099 | 0.80 | PRSS1 (0.62) | PRSS1KLK1F2TMPRSS2SLC22A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008142397-A1 | SERINE PROTEASE INHIBITORS FOR USE IN THE TREATMENT OF BACTERIAL INFECTIONS | SERENTIS LIMITED (GB) | 2008-11-27 | — | — | WO | disclosed |