Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 5/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9365777 | 0.93 | SOS1 (0.44) | SOS1HSPB1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL10904311 | 0.74 | MMP14 (0.43) | MAOBALDH1A1GAAMEN1KMT2A | |
| SCHEMBL15469444 | 0.74 | KDM4E (0.38) | NFE2L2SOS1HSPB1MAOBCA1 | |
| SCHEMBL13905968 | 0.74 | CYP2A6 (0.42) | MAOBCA1CA2CA9ALDH1A1 | |
| SCHEMBL4753435 | 0.74 | CA1 (0.58) | CA1CA2CA7CA9ALDH1A1 | |
| SCHEMBL1417001 | 0.74 | LMNA (0.42) | MAOBCA1CA2CA9ALDH1A1 | |
| SCHEMBL5848380 | 0.74 | NFE2L2 (0.37) | NFE2L2SOS1HSPB1MAOBCA1 | |
| SCHEMBL95869 | 0.74 | SOS1 (0.39) | NFE2L2SOS1HSPB1MAOBCA1 | |
| SCHEMBL169455 | 0.72 | — | — | |
| SCHEMBL14632031 | 0.72 | NFE2L2 (0.39) | NFE2L2MAOBACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616077-B1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | UNIV LEUVEN KATH (BE) | 2016-08-31 | — | — | EP | claimed |
| EP-2405973-B1 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | UNIV LEUVEN KATH (BE) | 2015-04-22 | — | — | EP | claimed |
| EP-2178373-B1 | HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | ICAGEN INC (US) | 2013-01-23 | — | — | EP | claimed |
| EP-1603880-B1 | QUINOLINONE/BENZOXAZINONE DERIVATIVES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2008-05-07 | — | — | EP | claimed |
| EP-1506192-B1 | SUBSTITUTED PYRROLINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-02-27 | — | — | EP | claimed |
| EP-0295880-B1 | Substituted cyclic ketones, substituted cyclic enones, and process for producing the same | NISSAN CHEMICAL IND LTD (JP) | 1999-01-07 | — | — | EP | claimed |
| EP-0159584-B1 | N-(AZOLYLCARBAMOYL)-HYDROXYL AMINES AND FUNGICIDES CONTAINING THEM | BASF Aktiengesellschaft (DE) | 1989-01-18 | — | — | EP | claimed |
| EP-0013607-B1 | SUBSTITUTED BICYCLO (2,2,1)HEPTANES AND BICYCLO (2,2,1) HEPT-2-ENES AND THEIR PHARMACEUTICAL COMPOSITIONS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1983-03-23 | — | — | EP | claimed |
| WO-2024222614-A1 | HETEROCYCLIC GSPT1 DEGRADATION AGENT | 北京诺诚健华医药科技有限公司 | 2024-10-31 | — | — | WO | disclosed |
| EP-0520882-B1 | 2-Aminopyrimidin-4-carboxamide derivatives, their preparation and their application in therapy | SYNTHELABO (FR) | 1995-07-12 | — | — | EP | disclosed |
| EP-0520882-A1 | 2-Aminopyrimidin-4-carboxamide derivatives, their preparation and their application in therapy | SYNTHELABO (FR) | 1992-12-30 | — | — | EP | disclosed |