Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.81 |
| ▸ | TSHR | P16473 | 2/20 | 0.81 |
| ▸ | LMNA | P02545 | 3/20 | 0.80 |
| ▸ | HTT | P42858 | 2/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | DRD2 | P14416 | 4/20 | 0.68 |
| ▸ | DRD4 | P21917 | 4/20 | 0.68 |
| ▸ | DRD3 | P35462 | 4/20 | 0.68 |
| ▸ | HRH2 | P25021 | 3/20 | 0.68 |
| ▸ | HRH1 | P35367 | 2/20 | 0.68 |
| ▸ | HTR7 | P34969 | 4/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6906326 | 0.83 | KDM4E (0.67) | KDM4ETSHRLMNAHTTTDP1 | |
| SCHEMBL2316528 | 0.82 | KDM4E (0.77) | KDM4ETSHRLMNATDP1MAPK1 | |
| SCHEMBL4772684 | 0.82 | KDM4E (0.69) | KDM4ETSHRLMNAHTTTDP1 | |
| SCHEMBL15938480 | 0.81 | HTR7 (1.00) | KDM4ETSHRDRD2DRD4DRD3 | |
| SCHEMBL15937925 | 0.81 | HTR7 (1.00) | KDM4ETSHRLMNAHTTTDP1 | |
| SCHEMBL4754210 | 0.80 | KDM4E (1.00) | KDM4ETSHRLMNAHTTTDP1 | |
| SCHEMBL9831262 | 0.80 | KDM4E (0.64) | KDM4ETSHRLMNATDP1MAPK1 | |
| SCHEMBL28191688 | 0.79 | KDM4E (0.63) | KDM4ETSHRLMNATDP1MAPK1 | |
| SCHEMBL9720709 | 0.78 | KDM4E (0.71) | KDM4ETSHRLMNAHTTTDP1 | |
| SCHEMBL15937713 | 0.78 | HTR7 (1.00) | KDM4ELMNAHTTTDP1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |