Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TACR2 | P21452 | 1/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
| ▸ | TACR3 | P29371 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13982579 | 0.93 | KDM4E (0.52) | MAPK10MEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL13982678 | 0.87 | APP (0.47) | TSHRMEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL13982545 | 0.85 | MEN1 (0.46) | MAPK10TSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13982676 | 0.85 | TSHR (0.50) | TSHRMEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL4752731 | 0.83 | MEN1 (0.47) | MEN1KMT2ASMN1; SMN2GAAKDM4E | |
| SCHEMBL13982738 | 0.83 | ALDH1A1 (0.58) | MEN1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4751009 | 0.81 | APP (0.50) | MAPK10SMN1; SMN2GAAKDM4EALDH1A1 | |
| SCHEMBL13982677 | 0.80 | MEN1 (0.44) | TSHRMEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL4750732 | 0.80 | MEN1 (0.54) | TSHRMEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL4788878 | 0.79 | OXTR (0.45) | TSHRMEN1KMT2ASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |