Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | KLK1 | P06870 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | LSS | P48449 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753126 | 0.88 | ALDH1A1 (0.46) | APPFAAHKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4799893 | 0.88 | LMNA (0.50) | APPNPC1MAPK8MAPK10FAAH | |
| SCHEMBL13982579 | 0.82 | KDM4E (0.52) | NPC1MAPK10KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4753315 | 0.81 | MAPK10 (0.50) | MAPK10KDM4EMCHR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4751027 | 0.79 | APP (0.42) | APPNPC1MAPK8MAPK10KDM4E | |
| SCHEMBL4751013 | 0.77 | APP (0.40) | APPNPC1MAPK8MAPK10KDM4E | |
| SCHEMBL13982678 | 0.76 | APP (0.47) | APPNPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6630360 | 0.76 | SIGMAR1 (0.69) | FAAHKDM4EALDH1A1SMN1; SMN2LSS | |
| SCHEMBL4857441 | 0.75 | MEN1 (0.64) | MAPK10KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL1715769 | 0.74 | NPC1 (0.66) | NPC1KDM4EALDH1A1SMN1; SMN2KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |