Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4752360 | 0.87 | CYP1A2 (0.42) | CYP1A2CYP2C19LMNATP53HDAC1 | |
| SCHEMBL21254977 | 0.75 | RIPK1 (0.35) | CYP2C19RIPK1KMT2AALDH1A1KDM4E | |
| SCHEMBL11666016 | 0.71 | KMT2A (0.35) | CYP2C19RIPK1KMT2AALDH1A1KDM4E | |
| SCHEMBL4753717 | 0.71 | HCAR2 (0.44) | LMNAHDAC1HDAC8HDAC6KMT2A | |
| SCHEMBL1006964 | 0.71 | DHODH (0.47) | LMNAHDAC1HDAC8HDAC6KMT2A | |
| SCHEMBL11666350 | 0.70 | ALDH1A1 (0.33) | TP53RIPK1KMT2AALDH1A1KDM4E | |
| SCHEMBL18372860 | 0.69 | HCAR2 (0.47) | RIPK1KMT2ANPC1RAB9AGAA | |
| SCHEMBL8282611 | 0.69 | HCAR2 (0.61) | KMT2AHCAR2 | |
| SCHEMBL4751190 | 0.67 | HCAR2 (0.41) | CYP1A2CYP2C19HCAR2 | |
| SCHEMBL1423862 | 0.67 | CYP2C19 (0.62) | CYP1A2CYP2C19MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023178181-A1 | IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| EP-4245756-A1 | IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF | Gilead Sciences, Inc. (US) | 2023-09-20 | — | — | EP | disclosed |
| WO-2008148832-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEROF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-12-11 | — | — | WO | disclosed |
| WO-2008148832-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEROF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-12-11 | — | — | WO | disclosed |