SCHEMBL1006964

SCHEMBL1006964

FC(F)(F)c1n[nH]c2c1CCCC2

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 1/20 0.47
HCAR2 Q8TDS4 3/20 0.44
KMT2A Q03164 1/20 0.44
TSHR P16473 2/20 0.43
LMNA P02545 3/20 0.38
MAPK10 P53779 1/20 0.38
MAPT P10636 4/20 0.36
HPGD P15428 3/20 0.36
NPC1 O15118 2/20 0.36
GAA P10253 2/20 0.36
RAB9A P51151 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
RXFP1 Q9HBX9 1/20 0.35
HDAC1 Q13547 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
NPSR1 Q6W5P4 2/20 0.34
ALDH1A1 P00352 1/20 0.34
HTT P42858 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4753717 0.96 HCAR2 (0.44) DHODHHCAR2KMT2ATSHRLMNA
SCHEMBL14487622 0.84 DHODH (0.42) DHODHHCAR2KMT2ATSHRLMNA
SCHEMBL13054432 0.79 HCAR2 (0.44) DHODHHCAR2KMT2ATSHRLMNA
SCHEMBL14030325 0.75 HCAR2 (0.44) DHODHHCAR2KMT2ATSHRLMNA
SCHEMBL5644430 0.75 RBP4 (0.37)
SCHEMBL3978251 0.75 DHODH (0.35) DHODHHDAC1HDAC8HDAC6
SCHEMBL3982365 0.75 DHODH (0.32) DHODH
SCHEMBL1424414 0.73 HCAR2 (0.35) HCAR2HDAC1HDAC8HDAC6
Hydrochloric Acid SCHEMBL1263266 0.73 RBP4 (0.36)
SCHEMBL17066881 0.72 LMNA (0.44) DHODHHCAR2KMT2ATSHRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12295368-B2 Method for controlling hematophagous or sap-feeding arthropods BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSTIY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) 2025-05-13 US disclosed
CN-118056817-A Industrial synthesis method of GS6207 key intermediate 苏州匠化生物科技有限公司 2024-05-21 CN disclosed
US-20230312567-A1 CAPSID INHIBITORS FOR THE TREATMENT OF HIV GILEAD SCIENCES, INC. 2023-10-05 US disclosed
US-20230312567-A1 CAPSID INHIBITORS FOR THE TREATMENT OF HIV GILEAD SCIENCES, INC. 2023-10-05 US disclosed
US-20230276802-A1 Method for Controlling Hematophagous or Sap-Feeding Arthropods BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSTIY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) 2023-09-07 US disclosed
US-20230276802-A1 Method for Controlling Hematophagous or Sap-Feeding Arthropods BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSTIY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) 2023-09-07 US disclosed
US-11632953-B2 Method for controlling hematophagous or sap-feeding arthropods BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) 2023-04-25 US disclosed
US-11632953-B2 Method for controlling hematophagous or sap-feeding arthropods BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) 2023-04-25 US disclosed
US-20230012449-A1 COMPOUNDS FOR THE TREATMENT OF HIV GILEAD SCIENCES, INC. 2023-01-12 US disclosed
US-20230012449-A1 COMPOUNDS FOR THE TREATMENT OF HIV GILEAD SCIENCES, INC. 2023-01-12 US disclosed
WO-2008110566-A1 COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE GLAXO GROUP LIMITED (GB) 2008-09-18 WO disclosed
WO-2008110566-A1 COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE GLAXO GROUP LIMITED (GB) 2008-09-18 WO disclosed
US-20080045532-A1 Compounds which potentiate AMPA receptor and uses thereof in medicine GLAXO GROUP LIMITED (GB) 2008-02-21 US disclosed
US-20080045532-A1 Compounds which potentiate AMPA receptor and uses thereof in medicine GLAXO GROUP LIMITED (GB) 2008-02-21 US disclosed
US-20080045532-A1 Compounds which potentiate AMPA receptor and uses thereof in medicine GLAXO GROUP LIMITED (GB) 2008-02-21 US disclosed
WO-2008017932-A2 HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE PFIZER PRODUCTS INC. (US) 2008-02-14 WO disclosed
WO-2008017932-A2 HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE PFIZER PRODUCTS INC. (US) 2008-02-14 WO disclosed
WO-2008003452-A1 PYRAZOLEALKANAMIDE SUBSTITUTED THIOPHENES AS AMPA POTENTIATORS N.V. ORGANON (NL) 2008-01-10 WO disclosed
WO-2007107539-A1 COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE GLAXO GROUP LIMITED (GB) 2007-09-27 WO disclosed
WO-2007107539-A1 COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE GLAXO GROUP LIMITED (GB) 2007-09-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230312567-A1 CAPSID INHIBITORS FOR THE TREATMENT OF HIV HAVCR2, MAVS, CD4 DHODH 1833/4885HCAR2 2914/4885KMT2A 3427/4885
US-11632953-B2 Method for controlling hematophagous or sap-feeding arthropods KCNN1, KCNN2, KCNN3 DHODH 3473/4885HCAR2 3015/4885KMT2A 1449/4885
US-12295368-B2 Method for controlling hematophagous or sap-feeding arthropods KCNN1, KCNN2, KCNN3 DHODH 3473/4885HCAR2 3015/4885KMT2A 1449/4885
US-20080045532-A1 Compounds which potentiate AMPA receptor and uses thereof in medicine GRIN1, GRM2, GRM1 DHODH 3043/4885HCAR2 77/4885KMT2A 2334/4885
US-20230276802-A1 Method for Controlling Hematophagous or Sap-Feeding Arthropods KCNN1, KCNN2, KCNN3 DHODH 3473/4885HCAR2 3015/4885KMT2A 1449/4885
US-20230012449-A1 COMPOUNDS FOR THE TREATMENT OF HIV CCR5, NPC1, FURIN DHODH 248/4885HCAR2 3961/4885KMT2A 2804/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.