Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MPI | P34949 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | HTR1B | P28222 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753147 | 0.95 | ALDH1A1 (0.45) | ALDH1A1KDM4EKMT2AMAPTMPI | |
| SCHEMBL4750996 | 0.85 | ALDH1A1 (0.45) | ALDH1A1KDM4EKMT2AMAPTMPI | |
| SCHEMBL4751015 | 0.82 | MAPT (0.43) | ALDH1A1KDM4EKMT2AMAPTMPI | |
| SCHEMBL4753160 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EKMT2AL3MBTL1MEN1 | |
| SCHEMBL4753325 | 0.81 | ALDH1A1 (0.36) | ALDH1A1KDM4EKMT2AMAPTMPI | |
| SCHEMBL4750772 | 0.81 | ALDH1A1 (0.45) | ALDH1A1KDM4EKMT2AMAPTMPI | |
| SCHEMBL4751027 | 0.80 | APP (0.42) | ALDH1A1KDM4EKMT2AMAPTMPI | |
| SCHEMBL4753111 | 0.80 | ALDH1A1 (0.42) | ALDH1A1KDM4EKMT2AMAPTMPI | |
| SCHEMBL4751026 | 0.78 | MAPT (0.41) | ALDH1A1KDM4EKMT2AMAPTMPI | |
| SCHEMBL4751028 | 0.77 | ALDH1A1 (0.45) | ALDH1A1KDM4EKMT2AMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |