Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751002 | 0.90 | ALDH1A1 (0.47) | ALDH1A1KDM4EKMT2ATSHR | |
| SCHEMBL4753160 | 0.85 | ALDH1A1 (0.50) | ALDH1A1KDM4EKMT2ATSHRMAPK1 | |
| SCHEMBL4750996 | 0.82 | ALDH1A1 (0.45) | ALDH1A1KDM4EPOLBTDP1MAPT | |
| SCHEMBL4753147 | 0.82 | ALDH1A1 (0.45) | ALDH1A1KDM4EPOLBTDP1MAPT | |
| SCHEMBL6102352 | 0.81 | KDM4E (0.50) | ALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL4750797 | 0.78 | GRM5 (0.41) | ALDH1A1KDM4EPOLBMAPTKMT2A | |
| SCHEMBL4750772 | 0.78 | ALDH1A1 (0.45) | ALDH1A1KDM4EPOLBTDP1MAPT | |
| SCHEMBL5714960 | 0.78 | KDM4E (0.51) | ALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL4753111 | 0.78 | ALDH1A1 (0.42) | ALDH1A1KDM4EPOLBTDP1MAPT | |
| SCHEMBL4753349 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KDM4EPOLBTDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |