Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.36 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | DRD5 | P21918 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753367 | 1.00 | SMN1; SMN2 (0.40) | SMN1; SMN2POLBALDH1A1CRHR1DRD1 | |
| SCHEMBL4755169 | 0.91 | AVPR1A (0.39) | SMN1; SMN2POLBALDH1A1CRHR1DRD1 | |
| SCHEMBL4755166 | 0.91 | AVPR1A (0.39) | SMN1; SMN2POLBALDH1A1CRHR1DRD1 | |
| SCHEMBL13985522 | 0.83 | CRHR1 (0.41) | SMN1; SMN2POLBALDH1A1CRHR1DRD1 | |
| SCHEMBL4756481 | 0.83 | CRHR1 (0.41) | SMN1; SMN2POLBALDH1A1CRHR1DRD1 | |
| SCHEMBL4753376 | 0.81 | DRD1 (0.41) | SMN1; SMN2POLBALDH1A1DRD1DRD5 | |
| SCHEMBL13985505 | 0.81 | MCHR1 (0.35) | SMN1; SMN2POLBALDH1A1HPGDKDM4E | |
| SCHEMBL4790013 | 0.81 | MCHR1 (0.35) | SMN1; SMN2POLBALDH1A1HPGDKDM4E | |
| SCHEMBL13985497 | 0.81 | SMN1; SMN2 (0.40) | SMN1; SMN2POLBALDH1A1CRHR1DRD1 | |
| SCHEMBL4755592 | 0.81 | DRD1 (0.37) | SMN1; SMN2ALDH1A1DRD1DRD5HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |