Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | DRD1 | P21728 | 2/20 | 0.37 |
| ▸ | DRD5 | P21918 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | AOC2 | O75106 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755166 | 1.00 | AVPR1A (0.39) | AVPR1ASMN1; SMN2DRD1DRD5POLB | |
| SCHEMBL4755594 | 0.91 | DRD1 (0.37) | SMN1; SMN2DRD1DRD5ALDH1A1KMT2A | |
| SCHEMBL4755592 | 0.91 | DRD1 (0.37) | SMN1; SMN2DRD1DRD5ALDH1A1KMT2A | |
| SCHEMBL4753362 | 0.91 | SMN1; SMN2 (0.40) | SMN1; SMN2DRD1DRD5POLBALDH1A1 | |
| SCHEMBL4753367 | 0.91 | SMN1; SMN2 (0.40) | SMN1; SMN2DRD1DRD5POLBALDH1A1 | |
| SCHEMBL4755656 | 0.89 | MEN1 (0.39) | SMN1; SMN2POLBALDH1A1KMT2AMCHR1 | |
| SCHEMBL4755659 | 0.89 | MEN1 (0.39) | SMN1; SMN2POLBALDH1A1KMT2AMCHR1 | |
| SCHEMBL4753245 | 0.89 | DRD2 (0.41) | AVPR1ASMN1; SMN2DRD1DRD5ALDH1A1 | |
| SCHEMBL4753244 | 0.89 | DRD2 (0.41) | AVPR1ASMN1; SMN2DRD1DRD5ALDH1A1 | |
| SCHEMBL13985302 | 0.88 | TSHR (0.31) | AVPR1ADRD1DRD5CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | claimed |
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |