Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4756472 | 0.83 | KMT2A (0.54) | MAPTKMT2ANPSR1 | |
| SCHEMBL4756415 | 0.82 | KDM4E (0.45) | MAPTKDM4ELMNAPKMMAPK1 | |
| SCHEMBL4753631 | 0.79 | KMT2A (0.43) | MAPTKDM4ELMNAPKMMAPK1 | |
| SCHEMBL4753837 | 0.76 | DHFR (0.53) | — | |
| SCHEMBL4754937 | 0.75 | MAPT (0.48) | MAPT | |
| SCHEMBL4754986 | 0.75 | ALDH1A1 (0.49) | KMT2A | |
| SCHEMBL4755522 | 0.74 | KMT2A (0.46) | MAPTKDM4ELMNAPKMMAPK1 | |
| SCHEMBL11774942 | 0.74 | ALDH1A1 (0.50) | KDM4ELMNAKMT2A | |
| SCHEMBL4753632 | 0.74 | DHFR (0.43) | MAPTKDM4ELMNAPKMMAPK1 | |
| SCHEMBL4753250 | 0.73 | ALDH1A1 (0.56) | MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | claimed |
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | disclosed |