Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755522 | 0.85 | KMT2A (0.46) | KMT2AMAPTKDM4ELMNAPKM | |
| SCHEMBL4753605 | 0.79 | MAPT (0.44) | KMT2AMAPTKDM4ELMNAPKM | |
| SCHEMBL4753250 | 0.77 | ALDH1A1 (0.56) | KMT2AMAPTMEN1 | |
| SCHEMBL4753635 | 0.76 | BCHE (0.44) | KMT2AMAPTDHFRMEN1 | |
| SCHEMBL4756506 | 0.75 | DHFR (0.50) | KMT2ADHFRMEN1 | |
| SCHEMBL4756448 | 0.75 | DHFR (0.46) | DHFR | |
| SCHEMBL4756577 | 0.74 | MAPT (0.47) | KMT2AMAPTKDM4EDHFRMEN1 | |
| SCHEMBL4755176 | 0.73 | MAPT (0.41) | KMT2AMAPTKDM4ELMNAPKM | |
| SCHEMBL4756472 | 0.73 | KMT2A (0.54) | KMT2AMAPTNPSR1DHFRMEN1 | |
| SCHEMBL4755163 | 0.72 | MEN1 (0.46) | KMT2AMAPTDHFRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | claimed |
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | disclosed |