Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 10/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4756382 | 0.84 | DHFR (0.52) | DHFRHSP90AA1 | |
| SCHEMBL4753632 | 0.81 | DHFR (0.43) | DHFRKDM4ELMNAMAPTPKM | |
| SCHEMBL4756475 | 0.81 | DHFR (0.49) | DHFR | |
| SCHEMBL4755674 | 0.81 | DHFR (0.45) | DHFRKDM4EMAPTMAPK1HSP90AA1 | |
| SCHEMBL4753592 | 0.72 | DHFR (0.47) | DHFR | |
| SCHEMBL4753839 | 0.72 | DHFR (0.50) | DHFR | |
| SCHEMBL4753627 | 0.69 | ALOX5AP (0.38) | DHFR | |
| SCHEMBL4753151 | 0.69 | ALOX5AP (0.42) | DHFRKDM4E | |
| SCHEMBL4753630 | 0.68 | LCK (0.47) | — | |
| SCHEMBL30786197 | 0.68 | SMN1; SMN2 (0.55) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | claimed |
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | disclosed |