Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 19/20 | 0.47 |
| ▸ | KDR | P35968 | 9/20 | 0.47 |
| ▸ | JAK3 | P52333 | 5/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.47 |
| ▸ | KIT | P10721 | 12/20 | 0.43 |
| ▸ | SRC | P12931 | 11/20 | 0.43 |
| ▸ | TEK | Q02763 | 3/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21416962 | 0.78 | LCK (0.53) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL5489077 | 0.76 | LCK (0.50) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL5492585 | 0.71 | LCK (0.59) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL5488850 | 0.71 | LCK (0.62) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL4753607 | 0.68 | DHFR (0.45) | — | |
| SCHEMBL5496333 | 0.67 | LCK (0.59) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL42089 | 0.67 | LCK (0.73) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL14715547 | 0.67 | LCK (0.68) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL5492816 | 0.67 | LCK (0.72) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL23559590 | 0.66 | TDP1 (0.50) | LCKKDRJAK3MAPK14KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | claimed |
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | disclosed |