Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.32 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CFTR | P13569 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2270437 | 0.82 | RAB9A (0.38) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL13962776 | 0.69 | CES2 (0.37) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2273613 | 0.66 | ALDH1A1 (0.35) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2278283 | 0.66 | USP8 (0.35) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL19925907 | 0.65 | CES2 (0.47) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL29875006 | 0.65 | CES2 (0.47) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL31468409 | 0.64 | CES2 (0.50) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2274683 | 0.63 | MAPK14 (0.47) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2274679 | 0.63 | MAPK14 (0.47) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL12373218 | 0.63 | SMN1; SMN2 (0.34) | MEN1KMT2ACES2CES1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910348-A2 | BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007016392-A2 | BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |