Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | DRD5 | P21918 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | AOC2 | O75106 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753779 | 1.00 | MCHR1 (0.35) | MCHR1AVPR1ADRD1DRD5LMNA | |
| SCHEMBL13985528 | 0.90 | MCHR1 (0.38) | MCHR1AVPR1ADRD1DRD5LMNA | |
| SCHEMBL13985415 | 0.87 | AVPR1A (0.36) | MCHR1AVPR1ADRD1DRD5LMNA | |
| SCHEMBL4755639 | 0.86 | AVPR1A (0.38) | MCHR1AVPR1ADRD1DRD5LMNA | |
| SCHEMBL4755635 | 0.86 | AVPR1A (0.38) | MCHR1AVPR1ADRD1DRD5LMNA | |
| SCHEMBL4755622 | 0.85 | AVPR1A (0.37) | MCHR1AVPR1ADRD1DRD5LMNA | |
| SCHEMBL4755627 | 0.85 | AVPR1A (0.37) | MCHR1AVPR1ADRD1DRD5LMNA | |
| SCHEMBL4755166 | 0.81 | AVPR1A (0.39) | MCHR1AVPR1ADRD1DRD5LMNA | |
| SCHEMBL4755169 | 0.81 | AVPR1A (0.39) | MCHR1AVPR1ADRD1DRD5LMNA | |
| SCHEMBL13985427 | 0.80 | AVPR1A (0.34) | MCHR1AVPR1ADRD1DRD5AOC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |