Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.34 |
| ▸ | DRD5 | P21918 | 2/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AOC2 | O75106 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755639 | 1.00 | AVPR1A (0.38) | AVPR1ANOTUMKDM4EMAPTDRD1 | |
| SCHEMBL13985415 | 0.93 | AVPR1A (0.36) | AVPR1ANOTUMKDM4EMAPTDRD1 | |
| SCHEMBL4755622 | 0.90 | AVPR1A (0.37) | AVPR1ADRD1DRD5MCHR1LMNA | |
| SCHEMBL4755627 | 0.90 | AVPR1A (0.37) | AVPR1ADRD1DRD5MCHR1LMNA | |
| SCHEMBL13985226 | 0.89 | TBK1 (0.33) | AVPR1AKCNH2DRD2DRD3 | |
| SCHEMBL13985528 | 0.87 | MCHR1 (0.38) | AVPR1AMAPTDRD1DRD5MCHR1 | |
| SCHEMBL13985227 | 0.86 | NOTUM (0.39) | NOTUMKCNH2DRD2DRD3 | |
| SCHEMBL4753779 | 0.86 | MCHR1 (0.35) | AVPR1ADRD1DRD5MCHR1LMNA | |
| SCHEMBL4753777 | 0.86 | MCHR1 (0.35) | AVPR1ADRD1DRD5MCHR1LMNA | |
| SCHEMBL13985427 | 0.85 | AVPR1A (0.34) | AVPR1ADRD1DRD5MCHR1AOC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |