Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.39 |
| ▸ | FEN1 | P39748 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755194 | 0.84 | TSHR (0.60) | MAPK8MAPK10TSHRLMNATP53 | |
| Hydrochloric Acid SCHEMBL3466281 | 0.83 | SCN5A (0.51) | MAPK8MAPK10TSHRLMNATP53 | |
| Hydrochloric Acid SCHEMBL4753480 | 0.83 | TSHR (0.59) | MAPK8MAPK10TSHRLMNATP53 | |
| SCHEMBL3764364 | 0.79 | KMT2A (0.56) | KMT2AMAPK8MAPK10TSHRLMNA | |
| SCHEMBL1222370 | 0.78 | KMT2A (0.55) | KMT2AMAPK8MAPK10TSHRLMNA | |
| SCHEMBL4753812 | 0.77 | P2RX7 (0.51) | KMT2ATSHRLMNATP53ALOX15 | |
| SCHEMBL4753470 | 0.76 | SCD (0.51) | TSHR | |
| SCHEMBL4753765 | 0.75 | HCRTR1 (0.44) | KDM4ESCN5ASCN9A | |
| Hydrochloric Acid SCHEMBL3466569 | 0.75 | SCD (0.50) | TSHR | |
| Hydrochloric Acid SCHEMBL3466376 | 0.74 | HCRTR1 (0.43) | KDM4ESCN5ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008157844-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-12-24 | — | — | WO | disclosed |