Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11437323 | 0.85 | CYP1A2 (0.59) | CYP2C9CYP1A2 | |
| SCHEMBL3459786 | 0.84 | CYP1A2 (0.65) | CYP2C9CYP1A2ALDH1A1CYP2D6LMNA | |
| SCHEMBL475391 | 0.80 | CYP2C9 (0.49) | CYP2C9CYP1A2ALDH1A1CYP2D6LMNA | |
| P-Xylene SCHEMBL3752326 | 0.79 | CYP1A2 (0.70) | CYP2C9CYP1A2ALDH1A1NPSR1TP53 | |
| SCHEMBL31097886 | 0.77 | CYP2C9 (0.51) | CYP2C9CYP1A2ALDH1A1LMNATP53 | |
| SCHEMBL2534752 | 0.77 | CYP2C9 (0.84) | CYP2C9CYP1A2ALDH1A1CYP2D6LMNA | |
| SCHEMBL7799784 | 0.77 | CYP2C9 (0.51) | CYP2C9CYP1A2ALDH1A1CYP2D6NPSR1 | |
| SCHEMBL335423 | 0.75 | CYP1A2 (0.63) | CYP2C9CYP1A2ALDH1A1LMNAKDM4E | |
| SCHEMBL10387619 | 0.74 | CYP1A2 (0.61) | CYP2C9CYP1A2ALDH1A1CYP2D6LMNA | |
| SCHEMBL9194077 | 0.74 | CYP1A2 (0.61) | CYP2C9CYP1A2ALDH1A1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2412758-B1 | POLYION COMPLEX COMPRISING HYDROPHOBIZED POLYAMINO ACID AND USE OF THE SAME | UNIV KAGOSHIMA (JP) | 2017-05-10 | — | — | EP | disclosed |
| US-8853354-B2 | Polyion complex comprising hydrophobized polyamino acid and use of the same | KAGOSHIMA UNIVERSITY (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20120095186-A1 | POLYION COMPLEX COMPRISING HYDROPHOBIZED POLYAMINO ACID AND USE OF THE SAME | KAGOSHIMA UNIVERSITY (JP) | 2012-04-19 | — | — | US | disclosed |
| EP-2412758-A1 | POLYION COMPLEX COMPRISING HYDROPHOBIZED POLYAMINO ACID AND USE OF SAME | Kagoshima University (JP) | 2012-02-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095186-A1 | POLYION COMPLEX COMPRISING HYDROPHOBIZED POLYAMINO ACID AND USE OF THE SAME | PICALM, MICA, FIBP | CYP2C9 4630/4885CYP1A2 4801/4885ALDH1A1 4756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.