Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 1.00 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.39 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1748904 | 1.00 | HTR6 (1.00) | HTR6ALKTGFBR1ACVR1BACVR1 | |
| SCHEMBL1748316 | 1.00 | HTR6 (1.00) | HTR6ALKTGFBR1ACVR1BACVR1 | |
| Hydrochloric Acid SCHEMBL475692 | 0.99 | HTR6 (0.98) | HTR6ALKTGFBR1ACVR1BACVR1 | |
| Hydrochloric Acid SCHEMBL1748258 | 0.99 | HTR6 (0.98) | HTR6ALKTGFBR1ACVR1BACVR1 | |
| Hydrochloric Acid SCHEMBL1748380 | 0.99 | HTR6 (0.98) | HTR6ALKTGFBR1ACVR1BACVR1 | |
| Hydrochloric Acid SCHEMBL29391202 | 0.99 | HTR6 (0.98) | HTR6ALKTGFBR1ACVR1BACVR1 | |
| SCHEMBL5958552 | 0.95 | HTR6 (0.90) | HTR6ALKTGFBR1ACVR1BACVR1 | |
| SCHEMBL1748393 | 0.90 | HTR6 (0.82) | HTR6ALKTGFBR1ACVR1BACVR1 | |
| SCHEMBL10077171 | 0.90 | HTR6 (0.82) | HTR6ALKTGFBR1ACVR1BACVR1 | |
| Hydrochloric Acid SCHEMBL1748224 | 0.89 | HTR6 (0.80) | HTR6ALKTGFBR1ACVR1BACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8604021-B2 | Substituted arylamine compounds and methods of treatment | BECKER OREN (IL) | 2013-12-10 | — | — | US | claimed |
| US-20120115850-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND METHODS OF TREATMENT | BECKER OREN (IL) | 2012-05-10 | — | — | US | claimed |
| EP-2037925-B1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | GALENEA CORP (US) | 2012-02-01 | — | — | EP | claimed |
| US-7968538-B2 | Substituted arylamine compounds and methods of treatment | GALENEA CORP. (US) | 2011-06-28 | — | — | US | claimed |
| US-20100152141-A1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | EPIX DELAWARE, INC (US) | 2010-06-17 | — | — | US | claimed |
| US-20060205737-A1 | Substituted arylamine compounds and methods of treatment | GALENEA CORPORATION | 2006-09-14 | — | — | US | claimed |
| EP-3027613-B1 | PYRROLOQUINOLINE DERIVATIVES AS 5-HT6 ANTAGONISTS, PREPARATION METHOD AND USE THEREOF | UNIV JAGIELLONSKI (PL) | 2018-03-28 | — | — | EP | disclosed |
| EP-2582709-B1 | AZOLOPYRIDIN-3-ONE DERIVATIVES AS INHIBITORS OF LIPASES AND PHOSPHOLIPASES | SANOFI SA (FR) | 2018-01-24 | — | — | EP | disclosed |
| US-20170239237-A1 | PYRROLOQUINOLINE DERIVATIVES AS 5-HT6 ANTAGONISTS, PREPARATION METHOD AND USE THEREOF | UNIVERSITE DE MONTPELLIER (FR) | 2017-08-24 | — | — | US | disclosed |
| US-20170239237-A1 | PYRROLOQUINOLINE DERIVATIVES AS 5-HT6 ANTAGONISTS, PREPARATION METHOD AND USE THEREOF | UNIVERSITE DE MONTPELLIER (FR) | 2017-08-24 | — | — | US | disclosed |
| US-9676772-B2 | Pyrroloquinoline derivatives as 5-HT6 antagonists, preparation method and use thereof | Uniwersyter Jagiellonski (PL) | 2017-06-13 | — | — | US | disclosed |
| US-9676772-B2 | Pyrroloquinoline derivatives as 5-HT6 antagonists, preparation method and use thereof | Uniwersyter Jagiellonski (PL) | 2017-06-13 | — | — | US | disclosed |
| EP-2897939-B1 | BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES FOR TREATING METABOLIC OR CARDIOVASCULAR DISEASES | SANOFI SA (FR) | 2017-02-01 | — | — | EP | disclosed |
| EP-2037925-A1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | Epix Delaware, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2009021740-A2 | SUBSTITUTED TETRAHYDRONAPHTHALENES, PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF AS MEDICAMENTS | SANOFIS-AVENTIS (FR) | 2009-02-19 | — | — | WO | disclosed |
| US-20080171779-A1 | USE OF 5-HT6 ANTAGONISTS TO PREVENT RELAPSE INTO ADDICTION | SOLVAY PHARMACEUTICALS B.V. | 2008-07-17 | — | — | US | disclosed |
| US-20080171779-A1 | USE OF 5-HT6 ANTAGONISTS TO PREVENT RELAPSE INTO ADDICTION | SOLVAY PHARMACEUTICALS B.V. | 2008-07-17 | — | — | US | disclosed |
| WO-2008002539-A1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | EPIX DELAWARE, INC. (US) | 2008-01-03 | — | — | WO | disclosed |
| WO-2008002539-A1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | EPIX DELAWARE, INC. (US) | 2008-01-03 | — | — | WO | disclosed |
| US-20060205737-A1 | Substituted arylamine compounds and methods of treatment | GALENEA CORPORATION | 2006-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152141-A1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | HTR6, HTR3B, HTR1B | HTR6 1/4885ALK 2389/4885TGFBR1 2334/4885 |
| US-20080171779-A1 | USE OF 5-HT6 ANTAGONISTS TO PREVENT RELAPSE INTO ADDICTION | HTR6, HTR3B, HTR5A | HTR6 1/4885ALK 372/4885TGFBR1 2119/4885 |
| US-20120115850-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND METHODS OF TREATMENT | HTR6, HTR2A, HTR3B | HTR6 1/4885ALK 658/4885TGFBR1 3661/4885 |
| US-20170239237-A1 | PYRROLOQUINOLINE DERIVATIVES AS 5-HT6 ANTAGONISTS, PREPARATION METHOD AND USE THEREOF | HTR6, HTR2C, HTR3B | HTR6 1/4885ALK 1170/4885TGFBR1 2017/4885 |
| US-20060205737-A1 | Substituted arylamine compounds and methods of treatment | HTR6, HTR2A, HTR3B | HTR6 1/4885ALK 658/4885TGFBR1 3661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.