Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.44 |
| ▸ | PPARA | Q07869 | 6/20 | 0.44 |
| ▸ | MMP12 | P39900 | 2/20 | 0.42 |
| ▸ | PPARD | Q03181 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7730448 | 0.92 | HDAC1 (0.45) | HDAC1HDAC2HDAC3NCOR2HDAC6 | |
| SCHEMBL4755595 | 0.89 | FFAR1 (0.45) | PPARGPPARAMMP12PPARDHDAC1 | |
| SCHEMBL12894958 | 0.88 | HDAC3 (0.51) | HDAC1HDAC2HDAC3NCOR2CTSS | |
| SCHEMBL30724412 | 0.81 | HDAC1 (0.49) | MMP12HDAC1HDAC2HDAC3NCOR2 | |
| SCHEMBL4073146 | 0.80 | FFAR1 (0.46) | MMP12MMP3CTSSCTSKSLC6A2 | |
| SCHEMBL3050230 | 0.80 | MEN1 (0.46) | HDAC1HDAC2HDAC3NCOR2HDAC6 | |
| SCHEMBL6676150 | 0.80 | L3MBTL1 (0.46) | HDAC1HDAC2HDAC3NCOR2 | |
| SCHEMBL7998541 | 0.80 | ALOX5 (0.49) | HDAC1HDAC2HDAC3NCOR2CTSS | |
| SCHEMBL4658260 | 0.79 | FFAR1 (0.49) | PPARG | |
| SCHEMBL6676419 | 0.77 | L3MBTL1 (0.43) | HDAC1HDAC2HDAC3NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008157844-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-12-24 | — | — | WO | disclosed |