Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | SCN4A | P35499 | 7/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11370574 | 0.80 | — | — | |
| SCHEMBL14237494 | 0.78 | GRM4 (0.33) | HTR2BSCN4ASLC6A4CYP1A2CYP3A4 | |
| SCHEMBL9534758 | 0.77 | LMNA (0.41) | MEN1CYP2D6KMT2A | |
| SCHEMBL264457 | 0.75 | POLB (0.37) | HTR2CHTR2BSCN4ASLC6A4MEN1 | |
| SCHEMBL8494386 | 0.75 | CYP2C9 (0.33) | TSHR | |
| SCHEMBL1509392 | 0.75 | SCN4A (0.43) | HTR2CHTR2BPPARGSCN4ASLC6A4 | |
| SCHEMBL6950827 | 0.73 | IGLV6-57 (0.37) | HTR2CHTR2BSLC6A4SLC6A2MEN1 | |
| SCHEMBL7549734 | 0.73 | FFAR1 (0.33) | HTR2CHTR2BPPARGSLC6A4SLC6A2 | |
| SCHEMBL20912965 | 0.73 | HTR2C (0.40) | HTR2CHTR2BSLC6A4SLC6A2MEN1 | |
| SCHEMBL8095037 | 0.73 | HTR2C (0.40) | HTR2CHTR2BSLC6A4SLC6A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966222-A2 | PYRAZOLOTHIAZOLE PROTEIN KINASE MODULATORS | SGX Pharmaceuticals, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007059341-A2 | PYRAZOLOTHIAZOLE PROTEIN KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |
| EP-0047902-B1 | ACYLPHOSPHINESULFIDE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE | BASF Aktiengesellschaft (DE) | 1984-11-07 | — | — | EP | disclosed |