Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.68 |
| ▸ | FABP1 | P07148 | 1/20 | 0.67 |
| ▸ | FABP6 | P51161 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13149231 | 0.85 | TP53 (0.82) | TP53ALDH1A1KDM4EFABP1FABP6 | |
| SCHEMBL3242632 | 0.81 | TP53 (0.78) | TP53ALDH1A1KDM4EFABP1FABP6 | |
| SCHEMBL13546094 | 0.81 | ALDH1A1 (0.78) | TP53ALDH1A1KDM4EFABP1FABP6 | |
| SCHEMBL13546093 | 0.81 | FABP1 (1.00) | TP53ALDH1A1KDM4EFABP1FABP6 | |
| SCHEMBL3602106 | 0.80 | KMT2A (0.71) | KMT2AMEN1NPC1 | |
| SCHEMBL13546095 | 0.80 | KDM4E (0.94) | TP53ALDH1A1KDM4EFABP1FABP6 | |
| SCHEMBL29275417 | 0.80 | TP53 (0.76) | TP53ALDH1A1KDM4EFABP1FABP6 | |
| SCHEMBL7074145 | 0.78 | MC4R (0.69) | ALDH1A1KDM4EKMT2AMEN1LMNA | |
| SCHEMBL13150708 | 0.78 | FAAH (0.64) | KMT2AMEN1NPC1 | |
| SCHEMBL16026437 | 0.78 | ALDH1A1 (0.83) | TP53ALDH1A1KDM4EKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |