Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL498591 | 0.84 | PSEN1 (0.37) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL4757403 | 0.77 | MAPT (0.42) | GAAALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL499149 | 0.76 | SMN1; SMN2 (0.35) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL499150 | 0.73 | MAPT (0.38) | GAAMAPTKDM4E | |
| SCHEMBL4755992 | 0.68 | NOS2 (0.43) | KMT2AALDH1A1LMNAKDM4ETP53 | |
| SCHEMBL15107710 | 0.67 | ALDH1A1 (0.33) | GAAALDH1A1LMNAKDM4ECYP1A2 | |
| SCHEMBL499262 | 0.67 | NOS2 (0.41) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL8080309 | 0.67 | NOS2 (0.41) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL499213 | 0.65 | UTS2R (0.35) | GAAMAPTKDM4E | |
| SCHEMBL28963029 | 0.64 | MEN1 (0.64) | KMT2AMEN1GAAALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156816-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |