Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499150 | 0.86 | MAPT (0.38) | MAPTUTS2RKDM4EGAAMAPK1 | |
| SCHEMBL4754336 | 0.77 | KMT2A (0.37) | MAPTKDM4EGAALMNACYP1A2 | |
| SCHEMBL499213 | 0.76 | UTS2R (0.35) | MAPTUTS2RKDM4EGAAMAPK1 | |
| SCHEMBL498979 | 0.75 | UTS2R (0.33) | MAPTUTS2RKDM4EGAAMAPK1 | |
| SCHEMBL498881 | 0.73 | REN (0.41) | CYP3A4 | |
| SCHEMBL499139 | 0.73 | REN (0.41) | CYP3A4 | |
| SCHEMBL498591 | 0.73 | PSEN1 (0.37) | MAPTKDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL4755890 | 0.72 | AOC3 (0.44) | KDM4ECYP2D6 | |
| SCHEMBL4755992 | 0.71 | NOS2 (0.43) | KDM4ELMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL498970 | 0.70 | UTS2R (0.34) | MAPTUTS2RKDM4EGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156816-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |