Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13993091 | 0.80 | NOTUM (0.46) | NOTUMHDAC1HDAC6ALDH1A1GAA | |
| SCHEMBL1177124 | 0.80 | ALDH1A1 (0.58) | NOTUMPDK1PDK2PDK3PDK4 | |
| SCHEMBL1177381 | 0.76 | HSD17B10 (0.58) | NOTUMPDK1PDK2PDK3PDK4 | |
| SCHEMBL94509 | 0.75 | SMN1; SMN2 (0.53) | NOTUMALDH1A1GAAMEN1KMT2A | |
| SCHEMBL29522795 | 0.75 | SMN1; SMN2 (0.53) | NOTUMALDH1A1GAAMEN1KMT2A | |
| SCHEMBL2076187 | 0.75 | TP53 (0.40) | ALDH1A1GAAMEN1KMT2AMAPT | |
| SCHEMBL24316039 | 0.74 | NOTUM (0.46) | NOTUMHDAC1HDAC6PDK1PDK2 | |
| SCHEMBL7257879 | 0.74 | NOTUM (0.46) | NOTUMHDAC1HDAC6PDK1PDK2 | |
| SCHEMBL2625790 | 0.74 | ALDH1A1 (0.58) | NOTUMHDAC1HDAC6PDK1PDK2 | |
| SCHEMBL27570415 | 0.74 | SMN1; SMN2 (0.51) | NOTUMALDH1A1GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903612-B1 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS EPAC INHIBITORS | INST NAT SANTE RECH MED (FR) | 2019-07-10 | — | — | EP | disclosed |
| US-10093627-B2 | Tetrahydroquinoline derivatives and their use as Epac inhibitors | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2018-10-09 | — | — | US | disclosed |
| US-20180009757-A1 | Tetrahydroquinoline Derivatives and Their Use as Epac Inhibitors | Universite Paris-Saclay (FR) | 2018-01-11 | — | — | US | disclosed |
| US-9751838-B2 | Tetrahydroquinoline derivatives and their use as Epac inhibitors | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2017-09-05 | — | — | US | disclosed |
| US-20150252002-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS EPAC INHIBITORS | Universite Paris-Saclay (FR) | 2015-09-10 | — | — | US | disclosed |
| EP-2903612-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS EPAC INHIBITORS | Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) | 2015-08-12 | — | — | EP | disclosed |
| WO-2014053315-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS EPAC INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2014-04-10 | — | — | WO | disclosed |
| US-20080318999-A1 | Tricyclic Benzimidazoles and Their Use as Metabotropic Glutamate Receptor Modulators | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| US-20080318999-A1 | Tricyclic Benzimidazoles and Their Use as Metabotropic Glutamate Receptor Modulators | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| US-20080318999-A1 | Tricyclic Benzimidazoles and Their Use as Metabotropic Glutamate Receptor Modulators | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| EP-1912989-A2 | TRICYCLIC BENZIMIDAZOLES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007018998-A2 | TRICYCLIC BENZIMIDAZOLES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2007-02-15 | — | — | WO | disclosed |
| WO-2007018998-A2 | TRICYCLIC BENZIMIDAZOLES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2007-02-15 | — | — | WO | disclosed |
| US-20070032469-A1 | Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators | ASTRAZENECA AB (SE) | 2007-02-08 | — | — | US | disclosed |
| US-20070032469-A1 | Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators | ASTRAZENECA AB (SE) | 2007-02-08 | — | — | US | disclosed |
| US-20070032469-A1 | Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators | ASTRAZENECA AB (SE) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032469-A1 | Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators | GRM2, GRM1, GRIN2B | NOTUM 3896/4885HDAC1 298/4885HDAC6 313/4885 |
| US-20080318999-A1 | Tricyclic Benzimidazoles and Their Use as Metabotropic Glutamate Receptor Modulators | GRM2, GRM1, GRIN2B | NOTUM 3896/4885HDAC1 298/4885HDAC6 313/4885 |
| US-10093627-B2 | Tetrahydroquinoline derivatives and their use as Epac inhibitors | EPAS1, RAPGEF3, PRKCQ | NOTUM 3765/4885HDAC1 3452/4885HDAC6 4069/4885 |
| US-20180009757-A1 | Tetrahydroquinoline Derivatives and Their Use as Epac Inhibitors | EPAS1, RAPGEF3, PRKCQ | NOTUM 3765/4885HDAC1 3452/4885HDAC6 4069/4885 |
| US-20150252002-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS EPAC INHIBITORS | EPAS1, RAPGEF3, PRKCQ | NOTUM 3765/4885HDAC1 3452/4885HDAC6 4069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.