Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3866809 | 0.74 | PARP1 (0.44) | KDM4EHPGDALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL4755546 | 0.67 | KDM5A (0.49) | KDM5AKDM4CPKMHCAR2KDM4E | |
| SCHEMBL30388114 | 0.66 | PKM (1.00) | KDM5AKDM4CPKMHCAR2KDM4E | |
| SCHEMBL3118169 | 0.66 | PKM (1.00) | KDM5AKDM4CPKMHCAR2KDM4E | |
| SCHEMBL20240259 | 0.65 | ALDH1A1 (0.47) | KDM5AKDM4CPKMHCAR2KDM4E | |
| SCHEMBL30754559 | 0.64 | KDM5A (0.56) | KDM5AKDM4CPKMHCAR2KDM4E | |
| SCHEMBL11782800 | 0.64 | HSD17B10 (0.65) | KDM5AKDM4CPKMHCAR2KDM4E | |
| SCHEMBL20585318 | 0.63 | KMT2A (0.54) | KDM5AKDM4CPKMHCAR2KDM4E | |
| Ammonia Solution, Strong SCHEMBL11782697 | 0.63 | HSD17B10 (0.63) | KDM5AKDM4CPKMHCAR2KDM4E | |
| SCHEMBL23066107 | 0.62 | PKM (0.64) | KDM5AKDM4CPKMHCAR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001214-A2 | THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE, ISOXAZOLO[5,4-D]PYRIMIDIN-4(5H)-ONE AND ISOTHIAZOLO[5,4-D]PYRIMIDIN-4(5H)-ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-12-31 | — | — | WO | disclosed |