SCHEMBL4755060

SCHEMBL4755060

CC(=O)OC1(CNC(=O)OC(OC(=O)c2ccccc2)c2ccccc2)CCCCC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.39
CYP1A2 P05177 2/20 0.38
CYP2D6 P10635 2/20 0.38
LMNA P02545 2/20 0.38
SCN1A P35498 1/20 0.38
SCN2A Q99250 1/20 0.38
SCN3A Q9NY46 1/20 0.38
CYP3A4 P08684 2/20 0.37
ALDH1A1 P00352 2/20 0.37
SLC6A4 P31645 2/20 0.36
SLC6A3 Q01959 2/20 0.36
TSHR P16473 1/20 0.36
SLC6A2 P23975 1/20 0.36
MEN1 O00255 2/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
CTSK P43235 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4754475 0.87 LMNA (0.42) KMT2ACYP1A2CYP2D6LMNASCN1A
SCHEMBL5145749 0.85 LMNA (0.41) KMT2ACYP1A2CYP2D6LMNASCN1A
SCHEMBL5147240 0.84 ALDH1A1 (0.52) KMT2ACYP1A2CYP2D6LMNACYP3A4
SCHEMBL4757553 0.83 CTSK (0.39) KMT2ACYP1A2CYP2D6LMNASCN1A
SCHEMBL6886846 0.83 CTSK (0.35) KMT2ACYP1A2CYP2D6LMNASCN1A
SCHEMBL25331 0.81 GAA (0.39) KMT2ACYP1A2CYP2D6LMNASCN1A
SCHEMBL6882845 0.78 CYP2D6 (0.36) KMT2ACYP1A2CYP2D6LMNASCN1A
Acetic Acid SCHEMBL828255 0.78 CTSK (0.38) KMT2ACYP1A2CYP2D6LMNASCN1A
Acetic Acid SCHEMBL4755059 0.75 LMNA (0.48) CYP1A2CYP2D6LMNASCN1ASCN2A
SCHEMBL26773 0.75 TSHR (0.40) KMT2ALMNACYP3A4ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008157408-A2 USE OF PRODRUGS OF GABA ANALOGS, ANTISPASTICITY AGENTS, AND PRODRUGS OF GABA B RECEPTOR AGONISTS FOR TREATING SPASTICITY XENOPORT, INC. (US) 2008-12-24 WO disclosed
EP-1404324-A4 PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF XENOPORT INC (US) 2004-12-22 EP disclosed
EP-1404324-A2 PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF Xenoport, Inc. (US) 2004-04-07 EP disclosed
WO-2002100347-A2 PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF XENOPORT, INC. (US) 2002-12-19 WO disclosed