Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1447405 | 0.75 | LMNA (0.48) | RAB9ANPC1GAASMN1; SMN2TAS2R8 | |
| SCHEMBL4060937 | 0.72 | CSF1R (0.58) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL27534146 | 0.71 | CSF1R (0.47) | RAB9ANPC1SMN1; SMN2TAS2R8KMT2A | |
| SCHEMBL27534143 | 0.71 | CSF1R (0.47) | RAB9ANPC1SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL7159830 | 0.71 | P2RX7 (0.74) | RAB9ANPC1SMN1; SMN2KMT2AEPHX2 | |
| Hydrochloric Acid SCHEMBL1447733 | 0.70 | AOC1 (0.40) | KMT2AKDM4EALDH1A1MEN1LMNA | |
| SCHEMBL27909949 | 0.70 | NPC1 (0.59) | RAB9ANPC1GAASMN1; SMN2KMT2A | |
| SCHEMBL22862326 | 0.70 | EPHX2 (0.54) | RAB9ANPC1SMN1; SMN2KMT2AEPHX2 | |
| SCHEMBL17532581 | 0.69 | EPHX2 (0.57) | RAB9ANPC1SMN1; SMN2KMT2AEPHX2 | |
| SCHEMBL5273437 | 0.68 | KDM4E (0.44) | RAB9ANPC1GAASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912974-A1 | IMIDAZOLYL-PYRIMIDINE COMPOUNDS FOR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007015064-A1 | IMIDAZOLYL-PYRIMIDINE COMPOUNDS FOR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2007-02-08 | — | — | WO | disclosed |