Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 11/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 9/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499193 | 0.84 | ADRB3 (0.39) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL5069163 | 0.80 | ADRB3 (0.41) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL10324223 | 0.78 | SLC6A2 (0.49) | ADRB3ADRB1ADRB2SLC2A1 | |
| SCHEMBL16680070 | 0.74 | MEN1 (0.47) | ADRB3ADRB1ADRB2 | |
| SCHEMBL17398295 | 0.74 | ADRB3 (0.44) | ADRB3ADRB1ADRB2ADRA1DADRA1A | |
| SCHEMBL14402491 | 0.73 | ADRB1 (0.48) | ADRB3ADRB1ADRB2SLC2A1 | |
| SCHEMBL13849930 | 0.73 | ADRB1 (0.48) | ADRB3ADRB1ADRB2SLC2A1 | |
| SCHEMBL6690481 | 0.73 | ADRB1 (0.48) | ADRB3ADRB1ADRB2SLC2A1 | |
| SCHEMBL13849942 | 0.73 | ADRB1 (0.48) | ADRB3ADRB1ADRB2SLC2A1 | |
| SCHEMBL281883 | 0.72 | IDO1 (0.48) | ADRB3ADRB1ADRB2SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156816-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |