Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | LCAT | P04180 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | USP14 | P54578 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ERG | P11308 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.30 |
| ▸ | ITGAL | P20701 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755548 | 1.00 | PDE4B (0.35) | PDE4BPDE4DLCATCHEK1SYK | |
| SCHEMBL4755760 | 0.88 | PIK3CA (0.36) | PDE1APDE1BPDE1CLRRK2PIK3CA | |
| SCHEMBL4755763 | 0.88 | PIK3CA (0.36) | PDE1APDE1BPDE1CLRRK2PIK3CA | |
| SCHEMBL4755127 | 0.87 | PDE4B (0.35) | PDE4BPDE4DLCATCHEK1USP14 | |
| SCHEMBL4756551 | 0.84 | DRD1 (0.40) | — | |
| SCHEMBL4755225 | 0.84 | DRD1 (0.40) | — | |
| SCHEMBL4755228 | 0.84 | DRD1 (0.40) | — | |
| SCHEMBL13985416 | 0.79 | GPR119 (0.36) | PDE4BPDE4DLCATUSP14AR | |
| SCHEMBL3169713 | 0.79 | PDE4B (0.44) | PDE4BPDE4DLCATUSP14PIK3CD | |
| SCHEMBL3169708 | 0.79 | PDE4B (0.44) | PDE4BPDE4DLCATUSP14PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |