Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 2/20 | 0.31 |
| ▸ | DRD5 | P21918 | 2/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755760 | 1.00 | PIK3CA (0.36) | PIK3CACHRNB2CHRNA4YTHDC1LRRK2 | |
| SCHEMBL4755548 | 0.88 | PDE4B (0.35) | PIK3CALRRK2PDE1APDE1BPDE1C | |
| SCHEMBL4755555 | 0.88 | PDE4B (0.35) | PIK3CALRRK2PDE1APDE1BPDE1C | |
| SCHEMBL4755225 | 0.87 | DRD1 (0.40) | DRD1DRD5AVPR1A | |
| SCHEMBL4755228 | 0.87 | DRD1 (0.40) | DRD1DRD5AVPR1A | |
| SCHEMBL4756551 | 0.87 | DRD1 (0.40) | DRD1DRD5AVPR1A | |
| SCHEMBL4755767 | 0.79 | CHRNB2 (0.34) | PIK3CACHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4755765 | 0.79 | CHRNB2 (0.34) | PIK3CACHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4755529 | 0.79 | DRD1 (0.39) | DRD1DRD5AVPR1A | |
| SCHEMBL4755531 | 0.79 | DRD1 (0.39) | DRD1DRD5AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | claimed |