Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 4/20 | 0.40 |
| ▸ | DRD5 | P21918 | 4/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | MAT2A | P31153 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AOC2 | O75106 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | JUN | P05412 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755228 | 1.00 | DRD1 (0.40) | DRD1DRD5AVPR1AGRM1MAT2A | |
| SCHEMBL4755225 | 1.00 | DRD1 (0.40) | DRD1DRD5AVPR1AGRM1MAT2A | |
| SCHEMBL4755531 | 0.91 | DRD1 (0.39) | DRD1DRD5AVPR1AGRM1MAT2A | |
| SCHEMBL4755529 | 0.91 | DRD1 (0.39) | DRD1DRD5AVPR1AGRM1MAT2A | |
| SCHEMBL4755763 | 0.87 | PIK3CA (0.36) | DRD1DRD5AVPR1A | |
| SCHEMBL4755760 | 0.87 | PIK3CA (0.36) | DRD1DRD5AVPR1A | |
| SCHEMBL4911234 | 0.85 | DRD1 (0.42) | DRD1DRD5AVPR1AGRM1KCNH2 | |
| SCHEMBL4755555 | 0.84 | PDE4B (0.35) | — | |
| SCHEMBL4755548 | 0.84 | PDE4B (0.35) | — | |
| SCHEMBL4755753 | 0.82 | DRD1 (0.41) | DRD1DRD5AVPR1AGRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | claimed |