Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KAT7 | O95251 | 1/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | CFD | P00746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4754589 | 1.00 | REN (0.41) | RENSLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL5593634 | 0.89 | SLC6A2 (0.41) | RENSLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL5593564 | 0.89 | SLC6A2 (0.34) | RENSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5613173 | 0.88 | SLC6A2 (0.36) | RENSLC6A2SLC6A4SLC6A3KAT7 | |
| SCHEMBL8245173 | 0.82 | REN (0.45) | RENSLC6A2SLC6A4SLC6A3CYP3A4 | |
| SCHEMBL5593356 | 0.80 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4788823 | 0.80 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL5593346 | 0.80 | SLC6A2 (0.40) | RENSLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL5612896 | 0.79 | REN (0.33) | RENSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3941676 | 0.79 | REN (0.33) | RENSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156832-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |
| WO-2007117560-A2 | PIPERIDINE AND MORPHOLINE RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |