Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.73 |
| ▸ | RAB9A | P51151 | 9/20 | 0.73 |
| ▸ | NPC1 | O15118 | 8/20 | 0.73 |
| ▸ | STAT3 | P40763 | 7/20 | 0.73 |
| ▸ | PKM | P14618 | 4/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | HTT | P42858 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.73 |
| ▸ | MLNR | O43193 | 1/20 | 0.73 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.73 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.73 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.73 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19512170 | 0.90 | MEN1 (0.72) | MEN1KMT2ARAB9ANPC1STAT3 | |
| SCHEMBL19512169 | 0.88 | MEN1 (0.68) | MEN1KMT2ARAB9ANPC1STAT3 | |
| SCHEMBL19512174 | 0.87 | RAB9A (0.67) | MEN1KMT2ARAB9ANPC1STAT3 | |
| SCHEMBL12994083 | 0.86 | NPC1 (0.79) | MEN1KMT2ARAB9ANPC1STAT3 | |
| SCHEMBL19512176 | 0.86 | MEN1 (0.66) | MEN1KMT2ARAB9ANPC1STAT3 | |
| SCHEMBL19528610 | 0.85 | MEN1 (0.65) | MEN1KMT2ARAB9ANPC1STAT3 | |
| Nitazoxanide SCHEMBL5055353 | 0.84 | STAT3 (1.00) | MEN1KMT2ARAB9ANPC1STAT3 | |
| Nitazoxanide SCHEMBL40981 | 0.84 | STAT3 (1.00) | MEN1KMT2ARAB9ANPC1STAT3 | |
| Nitazoxanide SCHEMBL29373905 | 0.84 | STAT3 (1.00) | MEN1KMT2ARAB9ANPC1STAT3 | |
| SCHEMBL27134627 | 0.84 | MEN1 (0.76) | MEN1KMT2ARAB9ANPC1STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170362261-A1 | Tizoxanide Phosphate and Alkane Sulfonate and Pharmaceutical Applications Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2017-12-21 | — | — | US | claimed |
| EP-3239160-A1 | TIZOXANIDE PHOSPHATE AND ALKANE SULFONATE AND PHARMACEUTICAL APPLICATIONS THEREOF | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2017-11-01 | — | — | EP | claimed |
| US-10196411-B2 | Tizoxanide phosphate and alkane sulfonate and pharmaceutical applications thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2019-02-05 | — | — | US | disclosed |
| US-10196411-B2 | Tizoxanide phosphate and alkane sulfonate and pharmaceutical applications thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2019-02-05 | — | — | US | disclosed |
| US-20170362261-A1 | Tizoxanide Phosphate and Alkane Sulfonate and Pharmaceutical Applications Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2017-12-21 | — | — | US | disclosed |
| US-20170362261-A1 | Tizoxanide Phosphate and Alkane Sulfonate and Pharmaceutical Applications Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2017-12-21 | — | — | US | disclosed |
| US-20170362261-A1 | Tizoxanide Phosphate and Alkane Sulfonate and Pharmaceutical Applications Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2017-12-21 | — | — | US | disclosed |
| EP-3239160-A1 | TIZOXANIDE PHOSPHATE AND ALKANE SULFONATE AND PHARMACEUTICAL APPLICATIONS THEREOF | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2017-11-01 | — | — | EP | disclosed |
| EP-3239160-A1 | TIZOXANIDE PHOSPHATE AND ALKANE SULFONATE AND PHARMACEUTICAL APPLICATIONS THEREOF | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2017-11-01 | — | — | EP | disclosed |
| US-8895752-B2 | Alkylsulfonyl-substituted thiazolide compounds | ROMARK LABORATORIES L.C. (US) | 2014-11-25 | — | — | US | disclosed |
| US-8895752-B2 | Alkylsulfonyl-substituted thiazolide compounds | ROMARK LABORATORIES L.C. (US) | 2014-11-25 | — | — | US | disclosed |
| US-20120122939-A1 | ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS | ROMARK LABORATORIES, L.C. | 2012-05-17 | — | — | US | disclosed |
| US-20120122939-A1 | ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS | ROMARK LABORATORIES, L.C. | 2012-05-17 | — | — | US | disclosed |
| US-8124632-B2 | Alkylsulfonyl-substituted thiazolide compounds | ROMARK LABORATORIES, L.C. (US) | 2012-02-28 | — | — | US | disclosed |
| US-8124632-B2 | Alkylsulfonyl-substituted thiazolide compounds | ROMARK LABORATORIES, L.C. (US) | 2012-02-28 | — | — | US | disclosed |
| US-20090036467-A1 | ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS | ROMARK LABORATORIES L.C. | 2009-02-05 | — | — | US | disclosed |
| US-20090036467-A1 | ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS | ROMARK LABORATORIES L.C. | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10196411-B2 | Tizoxanide phosphate and alkane sulfonate and pharmaceutical applications thereof | TPI1, ALK, STS | MEN1 4147/4885KMT2A 3483/4885RAB9A 3060/4885 |
| US-20120122939-A1 | ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS | HAVCR2, EIF2AK2, AADAC | MEN1 4564/4885KMT2A 2303/4885RAB9A 1694/4885 |
| US-20170362261-A1 | Tizoxanide Phosphate and Alkane Sulfonate and Pharmaceutical Applications Thereof | TPI1, ALK, STS | MEN1 4147/4885KMT2A 3483/4885RAB9A 3060/4885 |
| US-20090036467-A1 | ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS | HAVCR2, EIF2AK2, AADAC | MEN1 4564/4885KMT2A 2303/4885RAB9A 1694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.