Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.46 |
| ▸ | PDE1A | P54750 | 5/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4937272 | 0.81 | SLC2A1 (0.39) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL4757488 | 0.73 | SLC2A1 (0.41) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL4756640 | 0.67 | GRM4 (0.50) | ALDH1A1MEN1KMT2AHPGDKDM4E | |
| SCHEMBL27792623 | 0.67 | NPC1 (0.60) | ALDH1A1HPGDKDM4ESMN1; SMN2PKM | |
| SCHEMBL10114926 | 0.66 | ALDH1A1 (0.38) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL12974234 | 0.66 | SMN1; SMN2 (0.47) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL4756815 | 0.65 | PDE5A (0.41) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL2154380 | 0.64 | KDM4E (0.67) | ALDH1A1HPGDKDM4ELMNAMAPK1 | |
| SCHEMBL4756354 | 0.64 | RAB9A (0.50) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL4756826 | 0.64 | RORC (0.43) | PDE5APDE1APDE1BPDE1CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895752-B2 | Alkylsulfonyl-substituted thiazolide compounds | ROMARK LABORATORIES L.C. (US) | 2014-11-25 | — | — | US | disclosed |
| US-20120122939-A1 | ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS | ROMARK LABORATORIES, L.C. | 2012-05-17 | — | — | US | disclosed |
| US-8124632-B2 | Alkylsulfonyl-substituted thiazolide compounds | ROMARK LABORATORIES, L.C. (US) | 2012-02-28 | — | — | US | disclosed |
| US-20090036467-A1 | ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS | ROMARK LABORATORIES L.C. | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122939-A1 | ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS | HAVCR2, EIF2AK2, AADAC | PDE5A 4694/4885PDE1A 4846/4885PDE1B 4830/4885 |
| US-20090036467-A1 | ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS | HAVCR2, EIF2AK2, AADAC | PDE5A 4694/4885PDE1A 4846/4885PDE1B 4830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.