Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13919311 | 0.86 | BRD4 (0.41) | IGF1RALDH1A1POLBKMT2ABRD4 | |
| SCHEMBL13919314 | 0.85 | IGF1R (0.36) | IGF1RALDH1A1POLBKMT2A | |
| SCHEMBL4480909 | 0.82 | IGF1R (0.46) | IGF1RALDH1A1POLBKMT2ABRD4 | |
| SCHEMBL4480914 | 0.76 | LDHA (0.33) | ALDH1A1POLBKMT2A | |
| SCHEMBL4492326 | 0.75 | RAB9A (0.51) | IGF1RALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL4499054 | 0.72 | IGF1R (0.35) | IGF1RALDH1A1POLBKMT2A | |
| SCHEMBL13919312 | 0.71 | IGF1R (0.48) | IGF1RALDH1A1POLBKMT2ABRD4 | |
| SCHEMBL4208158 | 0.71 | IGF1R (0.76) | IGF1RALDH1A1POLBKMT2ABRD4 | |
| SCHEMBL4480832 | 0.71 | IGF1R (0.34) | IGF1RALDH1A1POLBKMT2A | |
| SCHEMBL4505680 | 0.70 | IGF1R (0.34) | IGF1RALDH1A1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | disclosed |
| EP-1651599-A4 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2008-09-24 | — | — | EP | disclosed |
| EP-1651599-A1 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005009957-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2005-02-03 | — | — | WO | disclosed |