Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 12/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755631 | 1.00 | HSD11B1 (0.51) | HSD11B1CYP2D6NPY5RHRH3SIGMAR1 | |
| SCHEMBL4759117 | 0.80 | HSD11B1 (0.61) | HSD11B1CYP2D6NPY5RHRH3SIGMAR1 | |
| SCHEMBL4759115 | 0.80 | HSD11B1 (0.61) | HSD11B1CYP2D6NPY5RHRH3SIGMAR1 | |
| SCHEMBL4757502 | 0.79 | HSD11B1 (0.52) | HSD11B1CYP2D6NPY5RHRH3SIGMAR1 | |
| SCHEMBL4757345 | 0.76 | HSD11B1 (0.64) | HSD11B1CYP2D6NPY5RAVPR1A | |
| SCHEMBL4757352 | 0.76 | HSD11B1 (0.64) | HSD11B1CYP2D6NPY5RAVPR1A | |
| SCHEMBL6079664 | 0.76 | HSD11B1 (0.61) | HSD11B1CYP2D6NPY5RHRH3SIGMAR1 | |
| SCHEMBL6080897 | 0.74 | HSD11B1 (0.61) | HSD11B1CYP2D6NPY5RAVPR1AALDH1A1 | |
| SCHEMBL6080875 | 0.74 | HSD11B1 (0.61) | HSD11B1CYP2D6NPY5RAVPR1AALDH1A1 | |
| SCHEMBL4759099 | 0.74 | ALDH1A1 (0.47) | HSD11B1HRH3ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758582-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2008-01-09 | — | — | EP | claimed |
| EP-1758582-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2006002349-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-01-05 | — | — | WO | claimed |