Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 11/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4759117 | 1.00 | HSD11B1 (0.61) | HSD11B1CYP2D6NPY5RAVPR1AHRH3 | |
| SCHEMBL4757502 | 0.92 | HSD11B1 (0.52) | HSD11B1CYP2D6NPY5RHRH3SIGMAR1 | |
| SCHEMBL4757345 | 0.85 | HSD11B1 (0.64) | HSD11B1CYP2D6NPY5RAVPR1A | |
| SCHEMBL4757352 | 0.85 | HSD11B1 (0.64) | HSD11B1CYP2D6NPY5RAVPR1A | |
| SCHEMBL4759150 | 0.82 | AVPR1A (0.46) | AVPR1AHRH3 | |
| SCHEMBL4759147 | 0.82 | AVPR1A (0.46) | AVPR1AHRH3 | |
| SCHEMBL6079664 | 0.82 | HSD11B1 (0.61) | HSD11B1CYP2D6NPY5RAVPR1AHRH3 | |
| SCHEMBL6080897 | 0.82 | HSD11B1 (0.61) | HSD11B1CYP2D6NPY5RAVPR1A | |
| SCHEMBL6080875 | 0.82 | HSD11B1 (0.61) | HSD11B1CYP2D6NPY5RAVPR1A | |
| SCHEMBL4757016 | 0.80 | HSD11B1 (0.51) | HSD11B1CYP2D6NPY5RAVPR1AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758582-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2008-01-09 | — | — | EP | claimed |
| EP-1758582-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2006002349-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-01-05 | — | — | WO | claimed |