Sugi Predict

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SCHEMBL4757499

SCHEMBL4757499

CCc1sc(NC(=O)c2ccc(Cl)c(Cl)c2OC(C)=O)nc1NS(C)(=O)=O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSD17B10 Q99714 1/20 0.35
▸ LMNA P02545 4/20 0.35
▸ ALDH1A1 P00352 4/20 0.35
▸ HTT P42858 1/20 0.35
▸ RORC P51449 1/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ MEN1 O00255 1/20 0.33
▸ POLB P06746 1/20 0.33
▸ KDM4E B2RXH2 3/20 0.33
▸ MAPT P10636 3/20 0.33
▸ RXFP1 Q9HBX9 2/20 0.33
▸ ADORA2A P29274 1/20 0.33
▸ ADORA2B P29275 1/20 0.33
▸ ADORA1 P30542 1/20 0.33
▸ NPC1 O15118 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ CYP2C9 P11712 1/20 0.33
▸ CYP2C19 P33261 1/20 0.33
▸ TP53 P04637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4756649 0.74 FFAR2 (0.44) HSD17B10LMNAALDH1A1HTTKMT2A
SCHEMBL4756828 0.74 RAB9A (0.38) HSD17B10ALDH1A1HTTRORCKMT2A
SCHEMBL4757495 0.67 KDM4E (0.36) HSD17B10ALDH1A1HTTKMT2AMEN1
SCHEMBL4757512 0.67 NPC1 (0.40) HSD17B10ALDH1A1HTTKMT2AMEN1
SCHEMBL10114468 0.66 RAB9A (0.38) HSD17B10ALDH1A1HTTRORCKMT2A
SCHEMBL10114354 0.66 FFAR2 (0.44) HSD17B10LMNAALDH1A1HTTKMT2A
SCHEMBL4757439 0.66 ALDH1A1 (0.42) HSD17B10LMNAALDH1A1HTTKMT2A
SCHEMBL4757405 0.66 MEN1 (0.46) LMNAALDH1A1KMT2AMEN1KDM4E
SCHEMBL4756762 0.65 RAB9A (0.41) HSD17B10LMNAALDH1A1HTTKMT2A
SCHEMBL4757501 0.64 POLB (0.37) LMNAALDH1A1HTTKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8895752-B2 Alkylsulfonyl-substituted thiazolide compounds ROMARK LABORATORIES L.C. (US) 2014-11-25 — — US disclosed
US-8895752-B2 Alkylsulfonyl-substituted thiazolide compounds ROMARK LABORATORIES L.C. (US) 2014-11-25 — — US disclosed
US-20120122939-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS ROMARK LABORATORIES, L.C. 2012-05-17 — — US disclosed
US-8124632-B2 Alkylsulfonyl-substituted thiazolide compounds ROMARK LABORATORIES, L.C. (US) 2012-02-28 — — US disclosed
US-20090036467-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS ROMARK LABORATORIES L.C. 2009-02-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122939-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS HAVCR2, EIF2AK2, AADAC HSD17B10 921/4885LMNA 2943/4885ALDH1A1 1605/4885
US-20090036467-A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS HAVCR2, EIF2AK2, AADAC HSD17B10 921/4885LMNA 2943/4885ALDH1A1 1605/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.