Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 13/20 | 0.55 |
| ▸ | ESR1 | P03372 | 13/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.55 |
| ▸ | TOP1 | P11387 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19493847 | 1.00 | HRAS (0.55) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL27281879 | 0.88 | HRAS (0.54) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL27271674 | 0.88 | HRAS (0.54) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL27277513 | 0.88 | HRAS (0.54) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL27275903 | 0.88 | HRAS (0.54) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL27272389 | 0.88 | HRAS (0.54) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL16469479 | 0.87 | HRAS (0.61) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL14003305 | 0.87 | HRAS (0.53) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL19636867 | 0.87 | HRAS (0.53) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL6497712 | 0.86 | KDM4E (0.59) | HRASESR1ESR2TOP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678133-A4 | SEQUENCE SELECTIVE PYRROLE AND IMIDAZOLE POLYAMIDE METALLOCOMPLEXES | UNIV WESTERN SYDNEY (AU) | 2008-06-18 | — | — | EP | disclosed |
| US-20070265240-A1 | Sequence Selective Pyrrole and Imidazole Polyamide Metallocomplexes | UNIVERSITY OF WESTERN SYDNEY (AU) | 2007-11-15 | — | — | US | disclosed |
| EP-1678133-A1 | SEQUENCE SELECTIVE PYRROLE AND IMIDAZOLE POLYAMIDE METALLOCOMPLEXES | University of Western Sydney (AU) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005033077-A1 | SEQUENCE SELECTIVE PYRROLE AND IMIDAZOLE POLYAMIDE METALLOCOMPLEXES | UNIVERSITY OF WESTERN SYDNEY (AU) | 2005-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265240-A1 | Sequence Selective Pyrrole and Imidazole Polyamide Metallocomplexes | POLRMT, MPI, PPIF | HRAS 4085/4885ESR1 4603/4885ESR2 4820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.