Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP4 | P49662 | 1/20 | 0.34 |
| ▸ | CASP5 | P51878 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL209888 | 0.87 | TRPC5 (0.40) | NPC1HTTTRPC5SIGMAR1CYP2C19 | |
| SCHEMBL209615 | 0.82 | MAPT (0.45) | RPS6KB1HTTCYP2C19MAPTSMN1; SMN2 | |
| SCHEMBL209456 | 0.82 | AURKA (0.41) | RPS6KB1NPC1HTTTRPC5SIGMAR1 | |
| SCHEMBL14495694 | 0.80 | HSP90AA1 (0.42) | RPS6KB1CYP2C19MAPTSMN1; SMN2LMNA | |
| SCHEMBL16152481 | 0.80 | MAPK10 (0.39) | RPS6KB1HTTSIGMAR1MAPTLMNA | |
| SCHEMBL208875 | 0.80 | RPS6KB1 (0.38) | RPS6KB1HTTCYP2C19MAPTSMN1; SMN2 | |
| SCHEMBL209669 | 0.79 | MEN1 (0.45) | RPS6KB1SIGMAR1CYP2C19CASP1CASP4 | |
| SCHEMBL208548 | 0.78 | POLB (0.53) | RPS6KB1CASP1CASP4CASP5MAPT | |
| SCHEMBL210676 | 0.78 | AURKA (0.42) | RPS6KB1CASP1CASP4CASP5MAPT | |
| SCHEMBL209541 | 0.77 | DRD2 (0.50) | CASP1CASP4CASP5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001021-A1 | IMIDAZOPYRIDINE DERIVATIVES USEFUL AS ENZYME INHIBITORS FOR THE TREATMENT OF CELL PROLIFERATIVE AND AUTOIMMUNE DISEASES | CHROMA THERAPEUTICS LTD. (GB) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001021-A1 | IMIDAZOPYRIDINE DERIVATIVES USEFUL AS ENZYME INHIBITORS FOR THE TREATMENT OF CELL PROLIFERATIVE AND AUTOIMMUNE DISEASES | CHROMA THERAPEUTICS LTD. (GB) | 2008-12-31 | — | — | WO | disclosed |