Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | PPM1B | O75688 | 1/20 | 0.32 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.32 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.32 |
| ▸ | PPP5C | P53041 | 1/20 | 0.32 |
| ▸ | PPP2CA | P67775 | 1/20 | 0.32 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13204860 | 1.00 | TP53 (0.32) | TP53CYP3A4MAPK1HIF1ALMNA | |
| SCHEMBL13204871 | 1.00 | TP53 (0.32) | TP53CYP3A4MAPK1HIF1ALMNA | |
| SCHEMBL13222520 | 1.00 | TP53 (0.32) | TP53CYP3A4MAPK1HIF1ALMNA | |
| SCHEMBL1034375 | 0.78 | — | — | |
| SCHEMBL1824543 | 0.77 | TP53 (0.33) | TP53CYP3A4MAPK1HIF1ALMNA | |
| SCHEMBL5305197 | 0.77 | TP53 (0.33) | TP53CYP3A4MAPK1HIF1ALMNA | |
| SCHEMBL5071496 | 0.68 | CYP3A4 (0.31) | CYP3A4 | |
| SCHEMBL10046442 | 0.67 | — | — | |
| SCHEMBL2971606 | 0.67 | — | — | |
| SCHEMBL13204847 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976382-B1 | PROCESS FOR PREPARING A SYNTHETIC INTERMEDIATE FOR PREPARATION OF BRANCHED NUCLEOSIDES | IDENIX PHARMACEUTICALS INC (US) | 2013-04-24 | — | — | EP | claimed |
| US-7781576-B2 | Process for preparing a synthetic intermediate for preparation of branched nucleosides | IDENIX PHARMACEUTICALS, INC. (US) | 2010-08-24 | — | — | US | claimed |
| EP-1976382-A2 | PROCESS FOR PREPARING A SYNTHETIC INTERMEDIATE FOR PREPARATION OF BRANCHED NUCLEOSIDES | IDENIX Pharmaceuticals, Inc. (US) | 2008-10-08 | — | — | EP | claimed |
| WO-2007075876-A2 | PROCESS FOR PREPARING A SYNTHETIC INTERMEDIATE FOR PREPARATION OF BRANCHED NUCLEOSIDES | IDENIX PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | claimed |
| US-10577359-B2 | Preparation of 2′-fluoro-2′-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives | GILEAD PHARMASSET LLC (US) | 2020-03-03 | — | — | US | disclosed |
| EP-1809301-B1 | 2-FLUORO-2-ALKYL-SUBSTITUTED D-RIBONOLACTONE INTERMEDIATES | GILEAD PHARMASSET LLC (US) | 2019-11-06 | — | — | EP | disclosed |
| US-20170253584-A1 | PREPARATION OF 2'-FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | GILEAD PHARMASSET LLC (US) | 2017-09-07 | — | — | US | disclosed |
| EP-3109244-A2 | PREPARATION OF 2'FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | Gilead Pharmasset LLC (US) | 2016-12-28 | — | — | EP | disclosed |
| US-20160024061-A1 | PREPARATION OF 2'-FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | PHARMASSET, INC. | 2016-01-28 | — | — | US | disclosed |
| CN-102199181-B | Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidines and purines and their derivatives | GILEAD PHARMASSET LLC | 2014-09-17 | — | — | CN | disclosed |
| US-20130338349-A1 | PREPARATION OF 2'-FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | PHARMASSET, INC. | 2013-12-19 | — | — | US | disclosed |
| US-8492539-B2 | Preparation of 2′-fluoro-2′-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives | GILEAD PHARMASSET LLC (US) | 2013-07-23 | — | — | US | disclosed |
| EP-1773856-A2 | PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | Pharmasset, Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| US-20060199783-A1 | Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidines and purines and their derivatives | PHARMASSETT, INC. (US) | 2006-09-07 | — | — | US | disclosed |
| US-20060199783-A1 | Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidines and purines and their derivatives | PHARMASSETT, INC. (US) | 2006-09-07 | — | — | US | disclosed |
| WO-2006012440-A3 | PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | PHARMASSET INC (US) | 2006-07-27 | — | — | WO | disclosed |
| US-20060122146-A1 | Preparation of 2'-fluoro-2'-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives | GILEAD SCIENCES, INC. | 2006-06-08 | — | — | US | disclosed |
| WO-2006031725-A2 | PREPARATION OF 2'FLUORO-2'- ALKYL- SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | PHARMASSET, INC. (US) | 2006-03-23 | — | — | WO | disclosed |
| WO-2006012440-A2 | PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | PHARMASSET, INC. (US) | 2006-02-02 | — | — | WO | disclosed |
| WO-2006012440-A2 | PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | PHARMASSET, INC. (US) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060199783-A1 | Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidines and purines and their derivatives | NSUN2, FBL, UMPS | TP53 2800/4885CYP3A4 863/4885MAPK1 3063/4885 |
| US-20160024061-A1 | PREPARATION OF 2'-FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | NSUN2, FBL, RNGTT | TP53 2566/4885CYP3A4 821/4885MAPK1 3198/4885 |
| US-20170253584-A1 | PREPARATION OF 2'-FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | NSUN2, FBL, RNGTT | TP53 2508/4885CYP3A4 842/4885MAPK1 3193/4885 |
| US-10577359-B2 | Preparation of 2′-fluoro-2′-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives | NSUN2, FBL, RNGTT | TP53 2634/4885CYP3A4 836/4885MAPK1 3158/4885 |
| US-20060122146-A1 | Preparation of 2'-fluoro-2'-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives | NSUN2, FBL, RNGTT | TP53 2508/4885CYP3A4 842/4885MAPK1 3193/4885 |
| US-20130338349-A1 | PREPARATION OF 2'-FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | NSUN2, FBL, RNGTT | TP53 2508/4885CYP3A4 842/4885MAPK1 3193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.