SCHEMBL4758532

SCHEMBL4758532

CC(C)c1cccc([C]=O)c1Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.40
GABRA1 P14867 3/20 0.40
CYP1A2 P05177 2/20 0.40
CYP3A4 P08684 2/20 0.40
GABRG2 P18507 2/20 0.40
GABRB3 P28472 2/20 0.40
GABRB2 P47870 2/20 0.40
FAAH O00519 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
HPGD P15428 1/20 0.40
TSHR P16473 1/20 0.40
GABRB1 P18505 1/20 0.40
PTGS1 P23219 1/20 0.40
SLC6A2 P23975 1/20 0.40
HTR2C P28335 1/20 0.40
GABRA5 P31644 1/20 0.40
GABRA3 P34903 1/20 0.40
HTR2B P41595 1/20 0.40
GABRA2 P47869 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16955505 0.80 LMNA (0.40) LMNAGABRA1CYP1A2CYP3A4GABRG2
SCHEMBL12251177 0.80 LMNA (0.40) LMNAGABRA1CYP1A2CYP3A4GABRG2
SCHEMBL535464 0.79 GABRA1 (0.44) LMNAGABRA1CYP1A2CYP3A4GABRG2
SCHEMBL2200187 0.78 GABRA1 (0.55) LMNAGABRA1CYP1A2CYP3A4GABRG2
SCHEMBL104772 0.78 CYP3A4 (0.32) GABRA1CYP1A2CYP3A4GABRB2TSHR
SCHEMBL3250611 0.78 GABRA1 (0.41) LMNAGABRA1CYP1A2CYP3A4GABRG2
SCHEMBL28273769 0.74 CYP1A2 (0.55) LMNAGABRA1CYP1A2CYP3A4GABRG2
SCHEMBL2053017 0.72 TSHR (0.38) CYP1A2CYP3A4CA1CA2TSHR
SCHEMBL95210 0.72 TSHR (0.42) LMNACYP1A2CYP3A4TSHRCYP2D6
SCHEMBL423182 0.72 CYP1A2 (0.68) LMNAGABRA1CYP1A2CYP3A4GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1963331-A1 AZEPINOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS Exelixis, Inc. (US) 2008-09-03 EP disclosed
WO-2007070796-A1 AZEPINOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS EXELIXIS, INC. (US) 2007-06-21 WO disclosed