Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.50 |
| ▸ | CA1 | P00915 | 4/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL9512094 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL17309684 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL9010920 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL163255 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL10773618 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL1919132 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL2127817 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL18042414 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL5173822 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL7762411 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109713335-B | Protection method for safe operation of molten carbonate fuel cell | 中国华能集团清洁能源技术研究院有限公司 | 2020-06-30 | — | — | CN | claimed |
| CN-109713335-A | A kind of guard method of molten carbonate fuel cell safe operation | 中国华能集团清洁能源技术研究院有限公司 | 2019-05-03 | — | — | CN | claimed |
| US-20140113942-A1 | PROCESS FOR THE PREPARATION AND PURIFICATION OF AZILSARTAN MEDOXOMIL | CADILA HEALTHCARE LIMITED (IN) | 2014-04-24 | — | — | US | claimed |
| EP-3712915-B1 | NON-AQUEOUS LITHIUM-TYPE ELECTRICITY STORAGE ELEMENT | ASAHI CHEMICAL IND (JP) | 2024-01-03 | — | — | EP | disclosed |
| US-11254675-B2 | Process for preparation of grapiprant | CADILA HEALTHCARE LIMITED (IN) | 2022-02-22 | — | — | US | disclosed |
| CN-113996291-A | Low-temperature HVOCs catalytic combustion catalyst, and preparation method and application thereof | 康纳新型材料(杭州)有限公司 | 2022-02-01 | — | — | CN | disclosed |
| US-20210347776-A1 | PROCESS FOR PREPARATION OF GRAPIPRANT | CADILA HEALTHCARE LIMITED (IN) | 2021-11-11 | — | — | US | disclosed |
| US-10988655-B2 | Composition for thermal storage and heat transfer applications | HINDUSTAN PETROLEUM CORPORATION LTD. (IN) | 2021-04-27 | — | — | US | disclosed |
| US-20210079000-A1 | PROCESS FOR PREPARATION OF GRAPIPRANT | CADILA HEALTHCARE LIMITED (IN) | 2021-03-18 | — | — | US | disclosed |
| EP-3712915-A1 | NON-AQUEOUS LITHIUM-TYPE ELECTRICITY STORAGE ELEMENT | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2020-09-23 | — | — | EP | disclosed |
| CN-109713335-B | Protection method for safe operation of molten carbonate fuel cell | 中国华能集团清洁能源技术研究院有限公司 | 2020-06-30 | — | — | CN | disclosed |
| US-20080157419-A1 | WET METHOD OF MANUFACTURING ELECTROLYTE-IMPREGNATED ELECTRODES FOR MOLTEN CARBONATE FUEL CELL | DOOSAN HEAVY INDUSTRIES & CONSTRUCTION CO., LTD. (KR) | 2008-07-03 | — | — | US | disclosed |
| US-20080094777-A1 | Electric double layer capacitor | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2008-04-24 | — | — | US | disclosed |
| EP-0184539-B1 | A BINARY ELECTROLYTE FOR MOLTEN CARBONATE FUEL CELLS | UNITED TECHNOLOGIES CORPORATION (US) | 1990-08-29 | — | — | EP | disclosed |
| EP-0335136-A1 | Calcium assay reagent | ABBOTT LABORATORIES (US) | 1989-10-04 | — | — | EP | disclosed |
| EP-0184539-A2 | A binary electrolyte for molten carbonate fuel cells | UNITED TECHNOLOGIES CORPORATION (US) | 1986-06-11 | — | — | EP | disclosed |
| US-4591538-A | Binary electrolyte for molten carbonate fuel cells | UNITED TECHNOLOGIES CORPORATION (US) | 1986-05-27 | — | — | US | disclosed |
| US-4252564-A | Method for cleaning bomb-reduced uranium derbies | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 1981-02-24 | — | — | US | disclosed |
| WO-1980002151-A1 | PROCESS AND APPARATUS FOR CARBONACEOUS MATERIAL CONVERSION | COSDEN TECHNOLOGY (US) | 1980-10-16 | — | — | WO | disclosed |
| US-4201760-A | LITHIUM SALT REACTED WITH ALUMINUM SALT | GENERAL ELECTRIC COMPANY (US) | 1980-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210347776-A1 | PROCESS FOR PREPARATION OF GRAPIPRANT | ADCYAP1R1, GANC, DRD4 | CA4 763/4885CA1 3764/4885CA2 2823/4885 |
| US-11254675-B2 | Process for preparation of grapiprant | ADCYAP1R1, GANC, DRD4 | CA4 763/4885CA1 3764/4885CA2 2823/4885 |
| US-20210079000-A1 | PROCESS FOR PREPARATION OF GRAPIPRANT | ADCYAP1R1, GANC, DRD4 | CA4 763/4885CA1 3764/4885CA2 2823/4885 |
| US-20140113942-A1 | PROCESS FOR THE PREPARATION AND PURIFICATION OF AZILSARTAN MEDOXOMIL | REN, AGTR2, AGTR1 | CA4 806/4885CA1 4248/4885CA2 908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.