Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4163337 | 0.83 | HSD17B14 (0.50) | HTTALOX15ALDH1A1KDM4EABCG2 | |
| SCHEMBL16880740 | 0.83 | HSD17B14 (0.51) | HTTALOX15ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL9222973 | 0.82 | MAPK1 (0.46) | HTTALOX15ALDH1A1KDM4EABCG2 | |
| SCHEMBL14339761 | 0.82 | MAPT (0.48) | HTTALOX15ALDH1A1KDM4EGAA | |
| SCHEMBL3364644 | 0.82 | LMNA (0.50) | HTTALOX15ALDH1A1KDM4EABCG2 | |
| SCHEMBL28071638 | 0.82 | RXFP1 (0.56) | ALDH1A1KDM4EABCG2HPGDL3MBTL1 | |
| SCHEMBL2004085 | 0.82 | ABCG2 (0.55) | HTTALOX15ALDH1A1KDM4EABCG2 | |
| SCHEMBL3361032 | 0.82 | HTT (0.41) | HTTALOX15ALDH1A1KDM4EABCG2 | |
| SCHEMBL7342388 | 0.82 | HDAC8 (0.55) | ALDH1A1KDM4EMAPTHPGDL3MBTL1 | |
| SCHEMBL31289295 | 0.82 | ABCG2 (0.55) | HTTALOX15ALDH1A1KDM4EABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101437797-A | Piperidine derivatives, their process for preparation, their use as therapeutic agents and pharmaceutical compositions containing them | ASTRAZENECA AB (SE) | 2009-05-20 | — | — | CN | disclosed |
| EP-1994003-A1 | PIPERIDINE DERIVATIVES, THEIR PROCESS FOR PREPARATION, THEIR USE AS THERAPEUTIC AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM . | AstraZeneca AB (SE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007102768-A1 | PIPERIDINE DERIVATIVES, THEIR PROCESS FOR PREPARATION, THEIR USE AS THERAPEUTIC AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM . | ASTRAZENECA AB (SE) | 2007-09-13 | — | — | WO | disclosed |