Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.77 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.77 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.74 |
| ▸ | MAOB | P27338 | 7/20 | 0.68 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.63 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.63 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.63 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | RXRA | P19793 | 1/20 | 0.58 |
| ▸ | RXRB | P28702 | 1/20 | 0.58 |
| ▸ | RXRG | P48443 | 1/20 | 0.58 |
| ▸ | PPARG | P37231 | 2/20 | 0.56 |
| ▸ | PPARD | Q03181 | 2/20 | 0.56 |
| ▸ | PPARA | Q07869 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13460803 | 0.89 | NR4A2 (0.66) | FFAR1FFAR4NR4A2MAOBRXRA | |
| SCHEMBL6839182 | 0.88 | MAOB (0.74) | FFAR1FFAR4NR4A2MAOBPDGFRA | |
| SCHEMBL14539208 | 0.85 | PTPRC (0.64) | FFAR1FFAR4NR4A2MRGPRX4RXRA | |
| SCHEMBL14014028 | 0.85 | NR4A2 (1.00) | FFAR1FFAR4NR4A2MAOBPDGFRA | |
| SCHEMBL3498978 | 0.84 | MAOB (0.67) | FFAR1MAOBMRGPRX4PTGDR2RXRA | |
| SCHEMBL5669711 | 0.82 | MAOB (0.74) | FFAR1FFAR4NR4A2MAOBPDGFRA | |
| Phenylacetic Acid SCHEMBL1807174 | 0.82 | MEN1 (0.66) | MAPTHTTRXRARXRBRXRG | |
| SCHEMBL378581 | 0.82 | MEN1 (0.65) | FFAR1FFAR4NR4A2MAPTHTT | |
| SCHEMBL29935522 | 0.82 | MEN1 (0.65) | FFAR1FFAR4NR4A2MAPTHTT | |
| SCHEMBL3575327 | 0.82 | PPARD (0.61) | FFAR1FFAR4NR4A2MAOBMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335655-B2 | 8-heteroaryl xanthine adenosine A2B receptor antagonists | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-7205403-B2 | 8-Heteroaryl xanthine adenosine A2B receptor antagonists | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-20060142309-A1 | 8-Heteroaryl xanthine adenosine A2B receptor antagonists | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. | 2006-06-29 | — | — | US | disclosed |
| EP-1469856-A4 | 8-HETEROARYL XANTHINE ADENOSINE A SB 2B /SB RECEPTOR ANTAGONISTS | KING PHARMACEUTICALS RES & DEV (US) | 2005-06-22 | — | — | EP | disclosed |
| EP-1469856-A2 | 8-HETEROARYL XANTHINE ADENOSINE A SB 2B /SB RECEPTOR ANTAGONISTS | King Pharmaceuticals Research and Development Inc. (US) | 2004-10-27 | — | — | EP | disclosed |
| US-20030207879-A1 | 8-Heteroaryl xanthine adenosine A2B receptor antagonists | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. | 2003-11-06 | — | — | US | disclosed |
| WO-2003063800-A2 | 8-HETEROARYL XANTHINE ADENOSINE A2B RECEPTOR ANTAGONISTS | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) | 2003-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207879-A1 | 8-Heteroaryl xanthine adenosine A2B receptor antagonists | ADORA2B, ADORA2A, ADORA1 | FFAR1 84/4885FFAR4 258/4885NR4A2 546/4885 |
| US-20060142309-A1 | 8-Heteroaryl xanthine adenosine A2B receptor antagonists | ADORA2B, ADORA2A, ADORA1 | FFAR1 161/4885FFAR4 396/4885NR4A2 694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.