Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3729769 | 0.83 | CYP2C19 (0.42) | CYP2C19HIF1ACYP1A2KMT2AMEN1 | |
| SCHEMBL27485164 | 0.78 | CYP1A2 (0.47) | CYP2C19HIF1ACYP1A2KMT2AMEN1 | |
| SCHEMBL18304346 | 0.76 | CYP1A2 (0.42) | CYP2C19HIF1ACYP1A2KMT2AKDM4E | |
| SCHEMBL8077580 | 0.75 | KIF11 (0.38) | OPRM1GRIN2DGRIN1GRIN2AGRIN2B | |
| SCHEMBL6898466 | 0.74 | CYP2C19 (0.46) | CYP2C19HIF1ACYP1A2KMT2AMEN1 | |
| SCHEMBL1670311 | 0.74 | CYP2C19 (0.46) | CYP2C19HIF1ACYP1A2KMT2AMEN1 | |
| SCHEMBL3726524 | 0.73 | PPARG (0.40) | CYP2C19HIF1ACYP1A2KMT2AKDM4E | |
| SCHEMBL7507490 | 0.73 | CYP1A2 (0.43) | CYP2C19HIF1ACYP1A2KMT2AMEN1 | |
| SCHEMBL4298978 | 0.73 | LMNA (0.46) | CYP2C19HIF1ACYP1A2KMT2AMEN1 | |
| SCHEMBL25372059 | 0.72 | CES1 (0.45) | CYP2C19HIF1ACYP1A2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945613-A1 | NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA | AstraZeneca AB (SE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007053082-A1 | NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |